Regulator G proteinske signalizacije 4 (RGS4) je protein koji reguliše G proteinsku signalizaciju.[1] Brojne sudije su ukazale na vezu RGS4 gena sa šizofrenijom,[2][3][4][5] mada postoje i studije koje nisu ustanovile vezu.[6]

Regulator G-proteinske signalizacije 4
PDB rendering based on 1agr.
Dostupne strukture
1agr​, 1ezt​, 1ezy
Identifikatori
Simboli RGS4; MGC2124; MGC60244; RGP4; SCZD9
Vanjski ID OMIM602516 MGI108409 HomoloGene4100 GeneCards: RGS4 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5999 19736
Ensembl ENSG00000117152 ENSMUSG00000038530
UniProt P49798 Q5D078
RefSeq (mRNA) NM_005613 NM_009062
RefSeq (protein) NP_005604 NP_033088
Lokacija (UCSC) Chr 1:
161.31 - 161.31 Mb
Chr 1:
171.58 - 171.58 Mb
PubMed pretraga [1] [2]

RGS4 je takođe od interesa kao jedan od tri glavna RGS proteina (zajedno sa RGS9 i RGS17) koji učestvuju u terminaciji signalizacije mi opioidnog receptora,[7] i moguće je da je značajan u razvoju tolerancije na opioidne lekove.[8][9][10][11][12]

Inhibitori

уреди

Interakcije

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Za RGS4 je pokazano da interaguje sa ERBB3,[15] GNAQ[16][17] i COPB2.[18]

Reference

уреди
  1. ^ „Entrez Gene: RGS4 regulator of G-protein signalling 4”. 
  2. ^ Stefanis NC, Trikalinos TA, Avramopoulos D, Smyrnis N, Evdokimidis I, Ntzani EE, Hatzimanolis A, Ioannidis JP, Stefanis CN (2008). „Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level”. Behavioral and Brain Functions. 4: 46. PMC 2572614 . PMID 18834502. doi:10.1186/1744-9081-4-46. 
  3. ^ Prasad KM, Almasy L, Gur RC, Gur RE, Pogue-Geile M, Chowdari KV, Talkowski ME, Nimgaonkar VL (2009). „RGS4 Polymorphisms Associated With Variability of Cognitive Performance in a Family-Based Schizophrenia Sample”. Schizophrenia Bulletin. 36 (5): 983—90. PMC 2930339 . PMID 19282471. doi:10.1093/schbul/sbp002. 
  4. ^ Dean B, Boer S, Gibbons A, Money T, Scarr E (2009). „Recent advances in postmortem pathology and neurochemistry in schizophrenia”. Current Opinion in Psychiatry. 22 (2): 154—60. PMID 19553869. doi:10.1097/YCO.0b013e328323d52e. 
  5. ^ Ding L, Hegde AN (2009). „Expression of RGS4 splice variants in dorsolateral prefrontal cortex of schizophrenic and bipolar disorder patients”. Biological Psychiatry. 65 (6): 541—5. PMID 19041089. doi:10.1016/j.biopsych.2008.10.026. 
  6. ^ Stuart Gibbons A, Scarr E, McOmish CE, Hannan AJ, Thomas EA, Dean B (2008). „Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia”. The Australian and New Zealand Journal of Psychiatry. 42 (8): 740—5. PMID 18622782. doi:10.1080/00048670802206338. 
  7. ^ Hooks SB, Martemyanov K, Zachariou V (2008). „A role of RGS proteins in drug addiction”. Biochemical Pharmacology. 75 (1): 76—84. PMID 17880927. doi:10.1016/j.bcp.2007.07.045. 
  8. ^ Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF (2005). „Generation and characterization of Rgs4 mutant mice”. Molecular and Cellular Biology. 25 (10): 4221—8. PMC 1087729 . PMID 15870291. doi:10.1128/MCB.25.10.4221-4228.2005. 
  9. ^ Garzón J, Rodríguez-Muñoz M, de la Torre-Madrid E, Sánchez-Blázquez P (2005). „Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS”. Psychopharmacology. 180 (1): 1—11. PMID 15830230. doi:10.1007/s00213-005-2248-9. 
  10. ^ Georgoussi Z, Leontiadis L, Mazarakou G, Merkouris M, Hyde K, Hamm H (2006). „Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling”. Cellular Signalling. 18 (6): 771—82. PMID 16120478. doi:10.1016/j.cellsig.2005.07.003. 
  11. ^ Leontiadis LJ, Papakonstantinou MP, Georgoussi Z (2009). „Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling”. Cellular Signalling. 21 (7): 1218—28. PMID 19324084. doi:10.1016/j.cellsig.2009.03.013. 
  12. ^ Wang Q, Liu-Chen LY, Traynor JR (2009). „Differential Modulation of {micro}- and {delta}-Opioid Receptor Agonists by Endogenous RGS4 Protein in SH-SY5Y Cells”. The Journal of Biological Chemistry. 284 (27): 18357—67. PMID 19416973. doi:10.1074/jbc.M109.015453. 
  13. ^ Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI (2004). „Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity”. Methods in Enzymology. 389: 266—77. PMID 15313571. doi:10.1016/S0076-6879(04)89016-5. 
  14. ^ Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR (2007). „Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay”. Molecular Pharmacology. 71 (1): 169—75. PMID 17012620. doi:10.1124/mol.106.028670. 
  15. ^ Thaminy, Safia; Auerbach Daniel; et al. (2003). „Identification of novel ErbB3-interacting factors using the split-ubiquitin membrane yeast two-hybrid system”. Genome Res. United States. 13 (7): 1744—53. ISSN 1088-9051. PMC 403748 . PMID 12840049. doi:10.1101/gr.1276503. 
  16. ^
  17. ^ Druey, K M; Sullivan B M; et al. (1998). „Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane”. J. Biol. Chem. UNITED STATES. 273 (29): 18405—10. ISSN 0021-9258. PMID 9660808. doi:10.1074/jbc.273.29.18405. 
  18. ^ Sullivan, B M; Harrison-Lavoie K J; et al. (2000). „RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport”. Mol. Biol. Cell. UNITED STATES. 11 (9): 3155—68. ISSN 1059-1524. PMC 14982 . PMID 10982407. 

Literatura

уреди