UGT1A4
UDP-glukuronoziltransferaza 1-4 je enzim koji je kod ljudi kodiran genom UGT1A4.[1][2][3]
Ovaj gen kodira UDP-glukuronoziltransferazu, enzim glukuronidacionog puta koji transformiše male lipofilne molekule, kao što su steroidi, bilirubin, hormoni i lekovi, u metabolite koji se mogu izlučiti u vodi. Ovaj gen je deo kompleksnog lokusa koji kodira nekoliko UDP-glukuronoziltransferaza. Lokus uključuje trinaest jedinstvenih alternativnih prvih eksona praćenih sa četiri zajednička eksona. Četiri alternativna prva egzona se smatraju pseudogenima. Svaki od preostalih devet 5′ eksona može biti spojen sa četiri zajednička eksona, što rezultira devet proteina sa različitim N-krajevima i identičnim C-krajevima. Svaki prvi ekson kodira mesto vezivanja supstrata i reguliše ga sopstveni promoter. Ovaj enzim ima određenu aktivnost glukuronidaze prema bilirubinu, iako je aktivniji na aminima, steroidima i sapogeninima.[3]
To je glavni enzim odgovoran za glukuronidaciju antikonvulzivnog lamotrigina.[4]
Reference
уреди- ^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (октобар 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.
- ^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (март 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J Biol Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4
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- ^ а б „Entrez Gene: UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4”.
- ^ Sandson NB, Armstrong SC, Cozza KL (2005). „An overview of psychotropic drug-drug interactions”. Psychosomatics. 46 (5): 464—94. PMID 16145193. doi:10.1176/appi.psy.46.5.464 .
Literatura
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