ALG2

ALG2
Identifikatori
Alijasi	ALG2
Spoljašnji ID	OMIM: 607905 MGI: 1914731 HomoloGene: 5930 GeneCards: ALG2
Genska lokacija (miš)
Hr.	Chromosome 4 (mouse)
Kraj	47,474,333 bp
Genska ontologija
Molecular function	• GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity; • transferase activity; • protein N-terminus binding; • protein heterodimerization activity; • glycosyltransferase activity; • GO:0001948, GO:0016582 vezivanje za proteine plazme; • calcium-dependent protein binding; • alpha-1,3-mannosyltransferase activity; • GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity;
Cellular component	• citoplazma; • sastavni deo membrane; • jedro; • membrana; • okojedarna oblast citoplazme; • endoplasmic reticulum membrane; • citosol; • actin cytoskeleton;
Biological process	• response to calcium ion; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • dolichol-linked oligosaccharide biosynthetic process; • mannosylation; • oligosaccharide-lipid intermediate biosynthetic process;
	Sources:Amigo / QuickGO
Ortolozi
	85365
	56737
	n/a
	ENSMUSG00000039740
	Q9H553
	Q9DBE8
	NM_033087; NM_197973
	NM_019998; NM_001355496
	NP_149078
	NP_064382; NP_001342425
	Wikidata
View/Edit Human	View/Edit Mouse

Alfa-1,3/1,6-manoziltransferaza ALG2 je enzim koji je kodiran ALG2 genom.^[4] Mutacije u ljudskom genu su povezane sa urođenim defektima u glikozilaciji.^[5]^[6] Protein kodiran genom ALG2 pripada dvema klasama enzima: GDP-Man:Man1GlcNAc2-PP-dolihol alfa-1,3-manoziltransferaza (EC 2.4.1.132) i GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza (EC 2.4.1.257).

Funkcija

Ovaj gen kodira člana porodice glikoziltransferaze 1. Kodirani protein deluje kao alfa 1,3 manoziltransferaza, manozilirajući Man(2)GlcNAc(2)-dolihol difosfat i Man(1)GlcNAc(2)-dolihol difosfat da bi se formirao Man(3)GlcNAc(2)-dolihol difosfat. Defekti ovog gena su povezani sa urođenim poremećajem glikozilacije tipa Ih (CDG-Ii).^[6]

Interakcije

Pokazano je da ALG2 formira interakcije sa ANXA7^[7] and ANXA11.^[7]

Reference

^ ^a ^b ^v GRCm38: Ensembl release 89: ENSMUSG00000039740 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jackson BJ, Kukuruzinska MA, Robbins P (avgust 1993). „Biosynthesis of asparagine-linked oligosaccharides in Saccharomyces cerevisiae: the alg2 mutation”. Glycobiology. 3 (4): 357—64. PMID 8400550. doi:10.1093/glycob/3.4.357. CS1 održavanje: Format datuma (veza)
^ Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T, Kohlschütter A, von Figura K, Lehle L, Körner C (jun 2003). „A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis”. The Journal of Biological Chemistry. 278 (25): 22498—505. PMID 12684507. doi:10.1074/jbc.M302850200  . CS1 održavanje: Format datuma (veza)
^ ^a ^b „Entrez Gene: ALG2 asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)”.
^ ^a ^b Satoh H, Nakano Y, Shibata H, Maki M (novembar 2002). „The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner”. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1600 (1–2): 61—7. PMID 12445460. doi:10.1016/S1570-9639(02)00445-4. CS1 održavanje: Format datuma (veza)

Literatura

Jaeken J (2005). „Congenital disorders of glycosylation (CDG): update and new developments”. Journal of Inherited Metabolic Disease. 27 (3): 423—6. PMID 15272470. S2CID 7608163. doi:10.1023/B:BOLI.0000031221.44647.9e.
Jaeken J, Carchon H (avgust 2004). „Congenital disorders of glycosylation: a booming chapter of pediatrics”. Current Opinion in Pediatrics. 16 (4): 434—9. PMID 15273506. doi:10.1097/01.mop.0000133636.56790.4a. CS1 održavanje: Format datuma (veza)
Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M (mart 2002). „ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner”. Biochemical and Biophysical Research Communications. 291 (5): 1166—72. PMID 11883939. doi:10.1006/bbrc.2002.6600. CS1 održavanje: Format datuma (veza) NB ALG-2 is NOT the protein product of the ALG2 gene.
Satoh H, Nakano Y, Shibata H, Maki M (novembar 2002). „The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner”. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1600 (1–2): 61—7. PMID 12445460. doi:10.1016/S1570-9639(02)00445-4. CS1 održavanje: Format datuma (veza) NB ALG-2 is NOT the protein product of the ALG2 gene.
Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (jun 2003). „The PEF family proteins sorcin and grancalcin interact in vivo and in vitro”. FEBS Letters. 545 (2–3): 151—4. PMID 12804766. S2CID 42572647. doi:10.1016/S0014-5793(03)00518-0. CS1 održavanje: Format datuma (veza)
Shibata H, Yamada K, Mizuno T, Yorikawa C, Takahashi H, Satoh H, Kitaura Y, Maki M (januar 2004). „The penta-EF-hand protein ALG-2 interacts with a region containing PxY repeats in Alix/AIP1, which is required for the subcellular punctate distribution of the amino-terminal truncation form of Alix/AIP1”. Journal of Biochemistry. 135 (1): 117—28. PMID 14999017. doi:10.1093/jb/mvh014. CS1 održavanje: Format datuma (veza) NB ALG-2 is NOT the protein product of the ALG2 gene.
Katoh K, Suzuki H, Terasawa Y, Mizuno T, Yasuda J, Shibata H, Maki M (novembar 2005). „The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B”. The Biochemical Journal. 391 (Pt 3): 677—85. PMC 1276969  . PMID 16004603. doi:10.1042/BJ20050398. CS1 održavanje: Format datuma (veza) NB ALG-2 is NOT the protein product of the ALG2 gene.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries”. DNA Research. 12 (2): 117—26. PMID 16303743. doi:10.1093/dnares/12.2.117  .
Draeby I, Woods YL, la Cour JM, Mollerup J, Bourdon JC, Berchtold MW (novembar 2007). „The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane”. Archives of Biochemistry and Biophysics. 467 (1): 87—94. PMC 2691584  . PMID 17889823. doi:10.1016/j.abb.2007.07.028. CS1 održavanje: Format datuma (veza) NB ALG-2 is NOT the protein product of the ALG2 gene.

Spoljašnje veze

GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
Human ALG2 genome location and ALG2 gene details page in the UCSC Genome Browser.

[refGRCm38Ensembl-1] v GRCm38: Ensembl release 89: ENSMUSG00000039740 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18400550-4] Jackson BJ, Kukuruzinska MA, Robbins P (avgust 1993). „Biosynthesis of asparagine-linked oligosaccharides in Saccharomyces cerevisiae: the alg2 mutation”. Glycobiology. 3 (4): 357—64. PMID 8400550. doi:10.1093/glycob/3.4.357. CS1 održavanje: Format datuma (veza)

[ThielSchwarz2003-5] Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T, Kohlschütter A, von Figura K, Lehle L, Körner C (jun 2003). „A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis”. The Journal of Biological Chemistry. 278 (25): 22498—505. PMID 12684507. doi:10.1074/jbc.M302850200  . CS1 održavanje: Format datuma (veza)

[entrez-6] „Entrez Gene: ALG2 asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)”.

[pmid12445460-7] Satoh H, Nakano Y, Shibata H, Maki M (novembar 2002). „The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner”. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1600 (1–2): 61—7. PMID 12445460. doi:10.1016/S1570-9639(02)00445-4. CS1 održavanje: Format datuma (veza)

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