Leukotrienski B₄ receptor 2

Leukotrienski B4 receptor 2
Leukotrienski B4 receptor 2
Identifikatori
Simboli	LTB4R2; BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2; LTB4-R2; NOP9
Vanjski ID	OMIM: 605773 MGI: 1888501 HomoloGene: 10519 IUPHAR: BLT2 GeneCards: LTB4R2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost leukotrienskog B4 receptora; • aktivnost prenosnika signala; • receptorska aktivnost; • aktivnost leukotrienskog receptora;
Celularna komponenta	• membranska frakcija; • ćelijska membrana; • integralno sa ćelijskom membranom; • integralno sa membranom;
Biološki proces	• hemotaksa; • prenos signala; • signalni put G-protein spregnutog receptora; • negativna regulacija adenilat ciklaze; • migracija keratinocita;
Ortolozi
Vrsta	Čovek
Entrez	56413
Ensembl	ENSG00000213906
UniProt	Q9NPC1
RefSeq (mRNA)	NM_001164692.2
RefSeq (protein)	NP_001158164.1
Lokacija (UCSC)	Chr 14:; 24.77 - 24.78 Mb
PubMed pretraga	[1]

Leukotrienski B4 receptor 2 je protein koji je kod ljudi kodiran LTB4R2 genom.^[1]^[2]^[3]

Ovaj receptor ima nizak afinitet za leukotriene. On posreduje hemotaksu granulocita i makrofaga.

Reference

^ Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T (2001). „A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization”. J Biol Chem. 275 (52): 40686—94. PMID 11006272. doi:10.1074/jbc.M004512200.
^ Kato K, Yokomizo T, Izumi T, Shimizu T (2000). „Cell-Specific Transcriptional Regulation of Human Leukotriene B4 Receptor Gene”. J Exp Med. 192 (3): 413—20. PMC 2193224  . PMID 10934229. doi:10.1084/jem.192.3.413.
^ „Entrez Gene: LTB4R2 leukotriene B4 receptor 2”.

Literatura

Tager AM, Luster AD (2004). „BLT1 and BLT2: the leukotriene B(4) receptors”. Prostaglandins Leukot. Essent. Fatty Acids. 69 (2–3): 123—34. PMID 12895595. doi:10.1016/S0952-3278(03)00073-5.
Kamohara M; Takasaki J; Matsumoto M; et al. (2000). „Molecular cloning and characterization of another leukotriene B4 receptor”. J. Biol. Chem. 275 (35): 27000—4. PMID 10889186. doi:10.1074/jbc.C000382200.
Tryselius Y; Nilsson NE; Kotarsky K; et al. (2000). „Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor”. Biochem. Biophys. Res. Commun. 274 (2): 377—82. PMID 10913346. doi:10.1006/bbrc.2000.3152.
Nilsson NE, Tryselius Y, Owman C (2000). „Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14”. Biochem. Biophys. Res. Commun. 274 (2): 383—8. PMID 10913347. doi:10.1006/bbrc.2000.3153.
Yokomizo T; Kato K; Terawaki K; et al. (2000). „A Second Leukotriene B4 Receptor, Blt2: A New Therapeutic Target in Inflammation and Immunological Disorders”. J. Exp. Med. 192 (3): 421—32. PMC 2193217  . PMID 10934230. doi:10.1084/jem.192.3.421.
Takeda S; Kadowaki S; Haga T; et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence”. FEBS Lett. 520 (1–3): 97—101. PMID 12044878. doi:10.1016/S0014-5793(02)02775-8.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Hashimoto A; Endo H; Hayashi I; et al. (2003). „Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis”. J. Rheumatol. 30 (8): 1712—8. PMID 12913925.
Yoo MH; Song H; Woo CH; et al. (2005). „Role of the BLT2, a leukotriene B4 receptor, in Ras transformation”. Oncogene. 23 (57): 9259—68. PMID 15489890. doi:10.1038/sj.onc.1208151.
Qiu H; Johansson AS; Sjöström M; et al. (2006). „Differential induction of BLT receptor expression on human endothelial cells by lipopolysacharide, cytokines, and leukotriene B4”. Proc. Natl. Acad. Sci. U.S.A. 103 (18): 6913—8. PMC 1440767  . PMID 16624877. doi:10.1073/pnas.0602208103.
Lundeen KA, Sun B, Karlsson L, Fourie AM (2006). „Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells”. J. Immunol. 177 (5): 3439—47. PMID 16920986.

Vidi još

Eikozanoidni receptor

Spoljašnje veze

IUPHAR GPCR Database - Leukotriene receptors Архивирано на сајту Wayback Machine (3. март 2016)
LTB4R2+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
Receptors,+Leukotriene+B4 на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid11006272-1] Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T (2001). „A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization”. J Biol Chem. 275 (52): 40686—94. PMID 11006272. doi:10.1074/jbc.M004512200.

[pmid10934229-2] Kato K, Yokomizo T, Izumi T, Shimizu T (2000). „Cell-Specific Transcriptional Regulation of Human Leukotriene B4 Receptor Gene”. J Exp Med. 192 (3): 413—20. PMC 2193224  . PMID 10934229. doi:10.1084/jem.192.3.413.

[entrez-3] „Entrez Gene: LTB4R2 leukotriene B4 receptor 2”.

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