MCM3
Faktor licenciranje DNK replikacije MCM3 je protein koji je kod ljudi kodiran MCM3 genom.
| Komponenta 3 kompleksa minihromozomskog održavanja | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | MCM3; HCC5; P1-MCM3; P1.h; RLFB | ||||||||||
| Vanjski ID | OMIM: 602693 MGI: 101845 HomoloGene: 1791 GeneCards: MCM3 Gene | ||||||||||
| EC broj | 3.6.4.12 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4172 | 17215 | |||||||||
| Ensembl | ENSG00000112118 | ENSMUSG00000041859 | |||||||||
| UniProt | P25205 | P25206 | |||||||||
| Ref. Sekv. (iRNK) | NM_001270472 | NM_008563 | |||||||||
| Ref. Sekv. (protein) | NP_001257401 | NP_032589 | |||||||||
| Lokacija (UCSC) |
Chr 6: 52.13 - 52.15 Mb |
Chr 1: 20.8 - 20.82 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Protein kodiran ovim genom je jedan od visoko konzerviranjih proteina održavanja mini-hromozoma (MCM) koji učestvuju u inicijaciji replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prereplikacionog kompleksa. On učestvuje u formiranju replikacionih viljuški i regrutaciji drugih srodnih proteina replikacije DNK[1][2].
Reference
uredi- ^ „Entrez Gene: MCM3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)”.
- ^ Thommes P, Fett R, Schray B, Burkhart R, Barnes M, Kennedy C, Brown NC, Knippers R (april 1992). „Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein”. Nucleic Acids Res. 20 (5): 1069—74. PMC 312092
. PMID 1549468. doi:10.1093/nar/20.5.1069.
Literatura
uredi- Musahl C, Schulte D, Burkhart R, Knippers R (1995). „A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins”. Eur. J. Biochem. 230 (3): 1096—101. PMID 7601140. doi:10.1111/j.1432-1033.1995.tb20660.x.
- Schulte D; Burkhart R; Musahl C; et al. (1995). „Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm 3 replication protein”. J. Cell. Sci. 108 (4): 1381—9. PMID 7615659.
- Starborg M; Brundell E; Gell K; et al. (1995). „A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication”. J. Cell. Sci. 108 (3): 927—34. PMID 7622621.
- Burkhart R; Schulte D; Hu D; et al. (1995). „Interactions of human nuclear proteins P1Mcm3 and P1Cdc46”. Eur. J. Biochem. 228 (2): 431—8. PMID 7705359. doi:10.1111/j.1432-1033.1995.tb20281.x.
- Kubota Y; Mimura S; Nishimoto S; et al. (1995). „Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor”. Cell. 81 (4): 601—9. PMID 7758114. doi:10.1016/0092-8674(95)90081-0.
- Madine MA, Khoo CY, Mills AD, Laskey RA (1995). „MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells”. Nature. 375 (6530): 421—4. PMID 7760938. doi:10.1038/375421a0.
- Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Hu B; Burkhart R; Schulte D; et al. (1994). „The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins”. Nucleic Acids Res. 21 (23): 5289—93. PMC 310560 . PMID 8265339. doi:10.1093/nar/21.23.5289-a.
- Schulte D; Richter A; Burkhart R; et al. (1996). „Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins”. Eur. J. Biochem. 235 (1–2): 144—51. PMID 8631321. doi:10.1111/j.1432-1033.1996.00144.x.
- Ishimi Y; Ichinose S; Omori A; et al. (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115—22. PMID 8798650. doi:10.1074/jbc.271.39.24115.
- Sato N, Arai K, Masai H (1997). „Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7”. EMBO J. 16 (14): 4340—51. PMC 1170060 . PMID 9250678. doi:10.1093/emboj/16.14.4340.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Takei Y, Tsujimoto G (1998). „Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization”. J. Biol. Chem. 273 (35): 22177—80. PMID 9712829. doi:10.1074/jbc.273.35.22177.
- Zhang JJ; Zhao Y; Chait BT; et al. (1999). „Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation”. EMBO J. 17 (23): 6963—71. PMC 1171044 . PMID 9843502. doi:10.1093/emboj/17.23.6963.
- Yankulov K; Todorov I; Romanowski P; et al. (1999). „MCM Proteins Are Associated with RNA Polymerase II Holoenzyme”. Mol. Cell. Biol. 19 (9): 6154—63. PMC 84545 . PMID 10454562.
- Fujita M; Yamada C; Goto H; et al. (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation”. J. Biol. Chem. 274 (36): 25927—32. PMID 10464337. doi:10.1074/jbc.274.36.25927.
- Kuwahara K; Yoshida M; Kondo E; et al. (2000). „A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication”. Blood. 95 (7): 2321—8. PMID 10733502.
- Hofmann Y; Becker J; Wright F; et al. (2000). „Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease”. Eur. J. Hum. Genet. 8 (3): 163—6. PMID 10780780. doi:10.1038/sj.ejhg.5200426.
- Abe E; Kuwahara K; Yoshida M; et al. (2000). „Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication”. Gene. 255 (2): 219—27. PMID 11024281. doi:10.1016/S0378-1119(00)00336-X.