VGF ili VGF induktivan nervnim faktorom rasta je protein i neuropeptid koji učestvuje u regulaciji energijske homeostaze, metabolizma[1] i sinaptičke plastičnosti.[2] Ovaj protein su otkrili 1985. Levi et al.[3] u eksperimentu sa PC12 ćelijama. VGF gen kodira prekurzor koji se proteolitički deli u polipeptide različitih masa, koji imaju mnoštovo funkcija. Najbolje izučena funkcija je uloga TLQP-21 u kontroli apetita i inflamacije.[4][5][6][7][8][9][10][11]

VGF induktivan nervnim faktorom rasta
Identifikatori
SimbolVGF
Entrez7425
HUGO12684
OMIM602186
RefSeqNM_003378
UniProtO15240
Ostali podaci
LokusHromozom 7 q22

Izražavanje VGF i peptida izvedenih iz VGF je detektovano u delu neurona centralnog i perifernog nervnog sistema i specifičnim populacijama endokrinih ćelija u adenohipofizi, adrenalnoj meduli, gastrointestinalnom traktu, i pancreasu.[12] VGF izražavanje indukuju NGF, CREB i BDNF, a reguliše neurotrofin-3.[13][14] Fizičko vežvanje znatno povišava VGF izražavanje u hipokampalnom tkivu miševa i povećava iražavanje neurotrofne signalne kaskade za koju se smatra da je u osnovi dejstva antidepresanata.[15][16][17][18]

Reference

uredi
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