Arilsulfataza B
Arilsulfataza B (ARSB) enzim je vezan za mukopolisaharidozu VI.
| Arilsulfataza B | |
|---|---|
 | |
| Identifikatori | |
| Simbol | ARSB |
| Entrez | 411 |
| HUGO | 714 |
| OMIM | 253200 |
| RefSeq | NM_000046 |
| UniProt | P15848 |
| Ostali podaci | |
| EC broj | 3.1.6.12 |
| Lokus | Hromozom 5 p11-q13 |
Arilsulfataza B je deo grupe arilsulfataznih enzima prisutnih u lizozomima jetre, pankreasa, i bubrega životinja. Svrha ovog enzima je hidroliza sulfata u telu. ARSB ne razlaže glikozaminoglikane (GAGs), koji su veliki šećerni molekuli tela. ARSB deluje na dva GAG molekula: dermatan sulfat i hondroitin sulfat.[2]
Reference
уреди- ^ PDB: 3ED4; Patskovsky Y, Ozyurt S, Gilmore M, Chang S, Bain K, Wasserman S, Koss J, Sauder MJ, Burley SK, Almo SC (2010). „Crystal structure of putative arylsulfatase from Escherichia coli”. To be Published. doi:10.2210/pdb3ed4/pdb.
- ^ U.S. National Library of Medicine. "ARSB", Genetics Home Resource, November 7, 2010, Retrieved November 22, 2010
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди
- Medical Dictionary, Arylsulfatase B function.
- Protein Data Base (PDB), Arylsulfatase structure.
- Genetics Home Reference, Arylsulfatase B function.