CXCL9, hemokine (C-X-C motif) ligand 9, je mali citokin iz CXC hemokin familije. On je takođe poznat kao monokin indukovan gama interferonom (MIG). CXCL9 je T-ćelijski hemoatraktant. On je blisko srodan sa dva druga CXC hemokina: CXCL10 i CXCL11, čiji geni su locirani u blizini CXCL9 gena na ljudskom hromozomu 4.[1][2] CXCL9, CXCL10 i CXCL11 invršavaju svoje hemotaksne funkcije putem interakcija sa hemokin receptorom CXCR3.[3][4]

Hemokin (C-X-C motiv) ligand 9
Identifikatori
Simboli CXCL9; CMK; Humig; MIG; SCYB9; crg-10
Vanjski ID OMIM601704 MGI1352449 HomoloGene1813 GeneCards: CXCL9 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4283 17329
Ensembl ENSG00000138755 ENSMUSG00000029417
UniProt Q07325 n/a
RefSeq (mRNA) NM_002416 NM_008599
RefSeq (protein) NP_002407 NP_032625
Lokacija (UCSC) Chr 4:
77.14 - 77.15 Mb
Chr 5:
93.4 - 93.4 Mb
PubMed pretraga [1] [2]

Interakcije

уреди

Za CXCL9 je bilo pokazano da ostvaruje interakcije sa CXCR3.[5][6]

Reference

уреди
  1. ^ Lee HH, Farber JM (1996). „Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster"”. Cytogenet. Cell Genet. 74 (4): 255—8. PMID 8976378. doi:10.1159/000134428. 
  2. ^ O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39—42. PMID 10343098. doi:10.1159/000015209. 
  3. ^ Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)”. J. Invest. Dermatol. 112 (5): 716—22. PMID 10233762. doi:10.1046/j.1523-1747.1999.00581.x. 
  4. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  5. ^ Lasagni, Laura; Francalanci Michela (2003). „An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4”. J. Exp. Med. United States. 197 (11): 1537—49. ISSN 0022-1007. PMC 2193908 . PMID 12782716. doi:10.1084/jem.20021897. 
  6. ^ Weng, Y; Siciliano S J (1998). „Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors”. J. Biol. Chem. UNITED STATES. 273 (29): 18288—91. ISSN 0021-9258. PMID 9660793. doi:10.1074/jbc.273.29.18288. 

Literatura

уреди

Dodatna literatura

уреди