FMO2

Dimetilanilin monooksigenaza (N-oksid-formirajuća) 2 je enzim koji je kod ljudi kodiran FMO2 genom.

FMO2
Identifikatori
Alijasi	FMO2
Spoljašnji ID	OMIM: 603955 MGI: 1916776 HomoloGene: 86882 GeneCards: FMO2
Genska lokacija (miš) Hr. Chromosome 1 (mouse) Band 1|1 H2.1 Start 162,701,886 bp Kraj 162,726,295 bp
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • oxidoreductase activity • N,N-dimethylaniline monooxygenase activity • NADP binding • flavin adenine dinucleotide binding • monooxygenase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • мембрана • ендоплазматични ретикулум • intracellular membrane-bounded organelle Biological process • xenobiotic metabolic process • toxin metabolic process • NADPH oxidation • NADP metabolic process • oxygen metabolic process • organic acid metabolic process Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	2327	55990
Ensembl	ENSG00000094963	ENSMUSG00000040170
UniProt	Q99518	Q8K2I3
RefSeq (mRNA)	NM_001301347 NM_001460 NM_001365900	NM_018881 NM_001360913 NM_001360914
RefSeq (protein)	NP_001288276 NP_001451 NP_001352829	NP_061369 NP_001347842 NP_001347843
Location (UCSC)	n/a	Chr 1: 162.7 – 162.73 Mb
PubMed search
Wikidata
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Monooksigenaze koje sarže flavin su NADPH zavisni enzimi koji katalizuju oksidaciju mnogih lekova i ksenobiotika. Kod većine sisara, monooksigenaze koje sadrže flavin katalizuju N-oksidaciju primarnih alkilamina putem N-hidroksilaminskih intermedijera. Međutim, kod ljudi ovaj enzim je okrnjen i verovatno se brzo ralaže. Protein kodiran ovim genom predstavlja skraćenu formu is stoga nema kataličko dejstvo. Objavljeno je da je kod afričkih amerikanaca funkcionalni alil prisutan, ali evidencija u vidu sekvence nije dostupna u prilog toj tvrdnji. Ovaj gen je lociran u klasteru sa FMO1, FMO3, i FMO4 genima na hromozomu 1.

Vidi još

• Dimetilanilin monooksigenaza (formiranje N-oksida)

Literatura

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