HAS1

Hijaluronanska sintaza 1 je enzim koji je kod ljudi kodiran genom HAS1.

HAS1
Identifikatori
Alijasi	HAS1
Spoljašnji ID	OMIM: 601463 MGI: 106590 HomoloGene: 1165 GeneCards: HAS1
Genska lokacija (miš) Hr. Chromosome 17 (mouse) Band 17 A3.2|17 10.53 cM Start 18,063,585 bp Kraj 18,075,467 bp
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • glycosyltransferase activity • transferase activity • hyaluronan synthase activity • GO:0001948, GO:0016582 везивање за протеине плазме • identical protein binding Cellular component • цитоплазма • саставни део мембране • ћелијска мембрана • integral component of plasma membrane • мембрана Biological process • Ćelijska adhezija • negative regulation of fibroblast migration • hyaluronan biosynthetic process • cellular response to platelet-derived growth factor stimulus • extracellular matrix assembly • glycosaminoglycan biosynthetic process • extracellular polysaccharide biosynthetic process • estrous cycle Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	3036	15116
Ensembl	ENSG00000105509	ENSMUSG00000003665
UniProt	Q92839	Q61647
RefSeq (mRNA)	NM_001297436 NM_001523	NM_008215
RefSeq (protein)	NP_001284365 NP_001514	NP_032241
Location (UCSC)	n/a	Chr 17: 18.06 – 18.08 Mb
PubMed search
Wikidata
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Literatura

• Spicer AP, Nguyen TK (1999). „Mammalian hyaluronan synthases: investigation of functional relationships in vivo.”. Biochem. Soc. Trans. 27 (2): 109—15. PMID 10093717. doi:10.1042/bst0270109. 
• Mian N (1987). „Analysis of cell-growth-phase-related variations in hyaluronate synthase activity of isolated plasma-membrane fractions of cultured human skin fibroblasts.”. Biochem. J. 237 (2): 333—42. PMC 1146992 . PMID 3099751. doi:10.1042/bj2370333. 
• Itano N, Kimata K (1996). „Molecular cloning of human hyaluronan synthase.”. Biochem. Biophys. Res. Commun. 222 (3): 816—20. PMID 8651928. doi:10.1006/bbrc.1996.0827. 
• Shyjan AM, Heldin P, Butcher EC, et al. (1996). „Functional cloning of the cDNA for a human hyaluronan synthase.”. J. Biol. Chem. 271 (38): 23395—9. PMID 8798544. doi:10.1074/jbc.271.38.23395 . 
• Simpson MA, Wilson CM, Furcht LT, et al. (2002). „Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.”. J. Biol. Chem. 277 (12): 10050—7. PMID 11790779. doi:10.1074/jbc.M110069200. 
• Calabro A, Oken MM, Hascall VC, Masellis AM (2002). „Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients.”. Blood. 100 (7): 2578—85. PMID 12239172. doi:10.1182/blood-2002-01-0030 . 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 . 
• Adamia S, Crainie M, Kriangkum J, et al. (2003). „Abnormal expression of hyaluronan synthases in patients with Waldenstrom's macroglobulimenia.”. Semin. Oncol. 30 (2): 165—8. PMID 12720129. doi:10.1053/sonc.2003.50042. 
• Suzuki K, Yamamoto T, Usui T, et al. (2004). „Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.”. Jpn. J. Ophthalmol. 47 (6): 557—64. PMID 14636845. doi:10.1016/j.jjo.2003.09.001. 
• Adamia S, Reiman T, Crainie M, et al. (2005). „Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma.”. Blood. 105 (12): 4836—44. PMC 1894997 . PMID 15731173. doi:10.1182/blood-2004-10-3825. 
• Yabushita H, Kishida T, Fusano K, et al. (2005). „Role of hyaluronan and hyaluronan synthase in endometrial cancer.”. Oncol. Rep. 13 (6): 1101—5. PMID 15870928. doi:10.3892/or.13.6.1101. 
• Stuhlmeier KM, Pollaschek C (2006). „Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation.”. J. Biol. Chem. 280 (52): 42766—73. PMID 16258173. doi:10.1074/jbc.M503374200. 
• Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). „Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells.”. Biochim. Biophys. Acta. 1760 (6): 890—5. PMID 16564133. doi:10.1016/j.bbagen.2006.02.002. 
• Kao JJ (2007). „The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.”. Exp. Gerontol. 41 (6): 641—7. PMID 16723203. S2CID 54406345. doi:10.1016/j.exger.2006.04.003. 
• Campo GM, Avenoso A, Campo S, et al. (2007). „TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.”. Mol. Cell. Biochem. 292 (1–2): 169—78. PMID 16786194. S2CID 37598580. doi:10.1007/s11010-006-9230-7. 
• Ewing RM, Chu P, Elisma F, et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry.”. Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134. 
• Meran S, Thomas D, Stephens P, et al. (2007). „Involvement of hyaluronan in regulation of fibroblast phenotype.”. J. Biol. Chem. 282 (35): 25687—97. PMID 17611197. doi:10.1074/jbc.M700773200 . 
• Kyossev Z, Weigel PH (2007). „An enzyme capture assay for analysis of active hyaluronan synthases.”. Anal. Biochem. 371 (1): 62—70. PMID 17904513. doi:10.1016/j.ab.2007.08.025.