Alfa lanac glikoproteinskih hormona je protein koji je kod ljudi kodiran CGA genom.[1]

Glikoproteinski hormoni, alfa polipeptid
PDB prikaz baziran na 1dz7​.
Dostupne strukture
1DZ7​, 1E9J​, 1FL7​, 1HCN​, 1HD4​, 1HRP​, 1QFW​, 1XWD​, 4AY9
Identifikatori
Simboli CGA; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
Vanjski ID OMIM118850 MGI88390 HomoloGene587 GeneCards: CGA Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 1081 12640
Ensembl ENSG00000135346 ENSMUSG00000028298
UniProt P01215 P01216
RefSeq (mRNA) NM_000735.3 NM_009889.2
RefSeq (protein) NP_000726.1 NP_034019.1
Lokacija (UCSC) Chr 6:
87.8 - 87.8 Mb
Chr 4:
34.89 - 34.91 Mb
PubMed pretraga [1] [2]

Četiri ljudska glikoproteinska hormona: humani horionski gonadotropin (hCG), luteinizirajući hormon (LH), folikulostimulišući hormon (FSH), i tireostimulišući hormon (TSH) su dimeri koji se sastoje od alfa i beta podjedinica, koje su nekovalentno vezane. Alfa podjedinice tih hormona su skoro identične, dok su njihovi beta lanci jedinstveni i definišu biološku specifičnost. Protein kodiran ovim genom je alfa podjedinica i pripada familiji alfa lanaca glikoproteinskih hormona.[2]

Alfa lanac ima sledeću aminokiselinsku sekvencu:

NH2 - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH

Aminokiselinska sekvena beta lanaca je:

NH2 - Ser - Lys - Glu - Pro - Leu - Arg - Pro - Arg - Cys - Arg - Pro - Ile - Asn - Ala - Thr - Leu - Ala - Val - Glu - Lys - Glu - Gly - Cys - Pro - Val - Cys - Ile - Thr - Val - Asn - Thr - Thr - Ile - Cys - Ala - Gly - Tyr - Cys - Pro - Thr - Met - Thr - Arg - Val - Leu - Gln - Gly - Val - Leu - Pro - Ala - Leu - Pro - Gln - Val - Val - Cys - Asn - Tyr - Arg - Asp - Val - Arg - Phe - Glu - Ser - Ile - Arg - Leu - Pro - Gly - Cys - Pro - Arg - Gly - Val - Asn - Pro - Val - Val - Ser - Tyr - Ala - Val - Ala - Leu - Ser - Cys - Gln - Cys - Ala - Leu - Cys - Arg - Arg - Ser - Thr - Thr - Asp - Cys - Gly - Gly - Pro - Lys - Asp - His - Pro - Leu - Thr - Cys - Asp - Asp - Pro - Arg - Phe - Gln - Asp - Ser - Ser - Ser - Ser - Lys - Ala - Pro - Pro - Pro - Ser - Leu - Pro - Ser - Pro - Ser - Arg - Leu - Pro - Gly - Pro - Ser - Asp - Thr - Pro - Ile - Leu - Pro - Gln - COOH

Reference

уреди
  1. ^ Fiddes JC, Goodman HM (1982). „The gene encoding the common alpha subunit of the four human glycoprotein hormones”. J Mol Appl Genet. 1 (1): 3—18. PMID 6286817. 
  2. ^ „Entrez Gene: CGA glycoprotein hormones, alpha polypeptide”. 

Literatura

уреди
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