Neurabin-2 je protein koji je kod ljudi kodiran PPP1R9B genom.[1][2]

Protein fosfataza 1, regulatorna podjedinica 9B
PDB prikaz baziran na 2g5m​.
Identifikatori
Simboli PPP1R9B; PPP1R6; PPP1R9; SPINO; Spn
Vanjski ID OMIM603325 MGI2387581 HomoloGene32787 GeneCards: PPP1R9B Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 84687 217124
Ensembl ENSG00000108819 ENSMUSG00000038976
UniProt Q96SB3 Q6R891
RefSeq (mRNA) NM_032595.3 NM_172261.3
RefSeq (protein) NP_115984.3 NP_758465.2
Lokacija (UCSC) Chr 17:
45.57 - 45.58 Mb
Chr 11:
94.85 - 94.87 Mb
PubMed pretraga [1] [2]

Spinofilin je regulatorni deo katalitičke jedinica proteinske fosfataze-1 (PP1). On je visoko izražen u dendritskim izbočinama, specijalizoanim delovima koji primaju veći deo ekscitatornog unosa u centralnom nervnom sistemu.[2]

Interakcije

уреди

PPP1R9B formira interakcije sa PPP1CB,[3] PPP1CA,[3] Dopamine receptor D2,[4] P16,[5] PPP1CC,[3][4] TIAM1[6] i PPP1R2.[7]

Reference

уреди
  1. ^ Allen PB, Ouimet CC, Greengard P (1997). „Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines”. Proc Natl Acad Sci U S A. 94 (18): 9956—61. PMC 23308 . PMID 9275233. doi:10.1073/pnas.94.18.9956. 
  2. ^ а б „Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B”. 
  3. ^ а б в Hsieh-Wilson, L C; Allen P B; et al. (1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1”. Biochemistry. UNITED STATES. 38 (14): 4365—73. ISSN 0006-2960. PMID 10194355. doi:10.1021/bi982900m. 
  4. ^ а б Smith, F D; Oxford G S; Milgram S L (1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein”. J. Biol. Chem. UNITED STATES. 274 (28): 19894—900. ISSN 0021-9258. PMID 10391935. doi:10.1074/jbc.274.28.19894. 
  5. ^ Vivo, M; Calogero R A; et al. (2001). „The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein”. J. Biol. Chem. United States. 276 (17): 14161—9. ISSN 0021-9258. PMID 11278317. doi:10.1074/jbc.M006845200. 
  6. ^ Buchsbaum, Rachel J; Connolly Beth A; Feig Larry A (2003). „Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin”. J. Biol. Chem. United States. 278 (21): 18833—41. ISSN 0021-9258. PMID 12531897. doi:10.1074/jbc.M207876200. 
  7. ^ Terry-Lorenzo, Ryan T; Elliot Elizabeth; et al. (2002). „Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton”. J. Biol. Chem. United States. 277 (48): 46535—43. ISSN 0021-9258. PMID 12270929. doi:10.1074/jbc.M206960200. 

Literatura

уреди