Интерлеукин 17A
(преусмерено са ИЛ-17А)
Интерлеукин 17A је протеин који је код људи кодиран IL17A геном.[1][2][3]
| Интерлеукин 17A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Идентификатори | |||||||||||
| Симболи | IL17A; CTLA8; IL-17; IL-17A; IL17 | ||||||||||
| Вањски ИД | OMIM: 603149 MGI: 107364 HomoloGene: 1651 GeneCards: IL17A Gene | ||||||||||
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| Преглед РНК изражавања | |||||||||||
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| подаци | |||||||||||
| Ортолози | |||||||||||
| Врста | Човек | Миш | |||||||||
| Ентрез | 3605 | 16171 | |||||||||
| Eнсембл | ENSG00000112115 | ENSMUSG00000025929 | |||||||||
| UниПрот | Q16552 | Q544E6 | |||||||||
| Реф. Секв. (иРНК) | NM_002190 | NM_010552 | |||||||||
| Реф. Секв. (протеин) | NP_002181 | NP_034682 | |||||||||
| Локација (УЦСЦ) |
Chr 6: 52.16 - 52.16 Mb |
Chr 1: 20.72 - 20.72 Mb | |||||||||
| ПубМед претрага | [1] | [2] | |||||||||
Протеин кодиран овим геном је проинфламаторни цитокин произведен активираним Т ћелијама.[4] Овај цитокин регулише активности НФ-капаБ и митоген активираних протеин киназа. Овај цитокин може да стимулише изражавање ИЛ-6 и циклооксигеназе-2 (PTGS2/COX-2), као и да појача продукцију нитрик оксида (NO). Високи нивои овог цитокина су асоцирани са неколико хроничних инфламаторних обољења укључујући реуматоидни артритис, псоријазу и мултиплу склерозу.[2]
Види још уреди
Референце уреди
- ^ Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P (1993). „CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene”. J Immunol. 150 (12): 5445—56. PMID 8390535.
- ^ а б „Entrez Gene: IL17A interleukin 17A”.
- ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
- ^ Thomas J. Kindt; Richard A. Goldsby; Barbara Anne Osborne; Janis Kuby (2006). Kuby Immunology (6 изд.). New York: W H Freeman and company. ISBN 1429202114.
Литература уреди
Додатна литература уреди
- SL, Gaffen (2005). „Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis.”. Arthritis Res. Ther. 6 (6): 240—7. PMC 1064872
. PMID 15535837. doi:10.1186/ar1444. - Lubberts E, Koenders MI, van den Berg WB (2006). „The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.”. Arthritis Res. Ther. 7 (1): 29—37. PMC 1064899 . PMID 15642151. doi:10.1186/ar1478.
- Z, Yao; Painter SL; Fanslow WC (1996). „Human IL-17: a novel cytokine derived from T cells.”. J. Immunol. 155 (12): 5483—6. PMID 7499828.
- F, Fossiez; Djossou O; Chomarat P (1996). „T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.”. J. Exp. Med. 183 (6): 2593—603. PMC 2192621 . PMID 8676080. doi:10.1084/jem.183.6.2593.
- Z, Yao; Spriggs MK; Derry JM (1998). „Molecular characterization of the human interleukin (IL)-17 receptor.”. Cytokine. 9 (11): 794—800. PMID 9367539. doi:10.1006/cyto.1997.0240.
- Murphy KP, Gagne P, Pazmany C, Moody MD (1998). „Expression of human interleukin-17 in Pichia pastoris: purification and characterization.”. Protein Expr. Purif. 12 (2): 208—14. PMID 9518462. doi:10.1006/prep.1997.0832.
- MB, Teunissen; Koomen CW; de Waal Malefyt R (1998). „Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.”. J. Invest. Dermatol. 111 (4): 645—9. PMID 9764847. doi:10.1046/j.1523-1747.1998.00347.x.
- Shalom-Barak T, Quach J, Lotz M (1998). „Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.”. J. Biol. Chem. 273 (42): 27467—73. PMID 9765276. doi:10.1074/jbc.273.42.27467.
- HC, Shin; Benbernou N; Fekkar H (1999). „Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway.”. Cytokine. 10 (11): 841—50. PMID 9878122. doi:10.1006/cyto.1998.0375.
- M, Laan; Cui ZH; Hoshino H (1999). „Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.”. J. Immunol. 162 (4): 2347—52. PMID 9973514.
- S, Kotake; Udagawa N; Takahashi N (1999). „IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.”. J. Clin. Invest. 103 (9): 1345—52. PMC 408356 . PMID 10225978. doi:10.1172/JCI5703.
- Shin HC, Benbernou N, Esnault S, Guenounou M (1999). „Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway.”. Cytokine. 11 (4): 257—66. PMID 10328864. doi:10.1006/cyto.1998.0433.
- A, Andoh; Takaya H; Makino J (2001). „Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells.”. Clin. Exp. Immunol. 125 (1): 56—63. PMC 1906093 . PMID 11472426. doi:10.1046/j.1365-2249.2001.01588.x.
- Laan M, Palmberg L, Larsson K, Lindén A (2002). „Free, soluble interleukin-17 protein during severe inflammation in human airways.”. Eur. Respir. J. 19 (3): 534—7. PMID 11936535. doi:10.1183/09031936.02.00280902.
- A, Andoh; Fujino S; Bamba S (2002). „IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts.”. J. Immunol. 169 (4): 1683—7. PMID 12165487.
- A, Andoh; Shimada M; Bamba S (2002). „Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts.”. Biochim. Biophys. Acta. 1591 (1-3): 69—74. PMID 12183057. doi:10.1016/S0167-4889(02)00250-1.
- Hsieh HG, Loong CC, Lin CY (2003). „Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells.”. Cytokine. 19 (4): 159—74. PMID 12297109. doi:10.1006/cyto.2002.1952.
- S, Aggarwal; Ghilardi N; Xie MH (2003). „Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.”. J. Biol. Chem. 278 (3): 1910—4. PMID 12417590. doi:10.1074/jbc.M207577200.
- Maertzdorf J, Osterhaus AD, Verjans GM (2003). „IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.”. J. Immunol. 169 (10): 5897—903. PMID 12421973.
Спољашње везе уреди
- Interleukin-17 на US National Library of Medicine Medical Subject Headings (MeSH)
