AR-A000002
AR-A000002 je lek, koji jedno od prvih jedinjenja razvijenih da deluje kao selektivni antagonist za serotoninski receptor 5-HT1B,[1] sa približno 10x većom selektivnošću za 5-HT1B u odnosu na srodni 5-HT1D receptor.[2] Bilo je pokazano da proizvodi održivo povećanje nivoa serotonina u mozgu, i da ima anksiolitsko dejstvo u životinjskim studijama.[3][4]
IUPAC ime | |
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(R)-N-[5-metil-8-(4-metilpiperazin-1-il)-1,2,3,4-tetrahidro-2-naftil]-4-morfolinobenzamid | |
Identifikatori | |
ATC kod | none |
PubChem | CID 9846516 |
ChemSpider | 8022230 |
Hemijski podaci | |
Formula | C27H36N4O2 |
Molarna masa | 448,599 g/mol |
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Reference уреди
- ^ Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C. Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist. Journal of Pharmacology and Experimental Therapeutics. 2003 Mar;304(3):1072-84. PMID 12604684
- ^ Ahlgren C, Eriksson A, Tellefors P, Ross SB, Stenfors C, Malmberg A. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist. European Journal of Pharmacology. 2004 Sep 19;499(1-2):67-75. PMID 15363952
- ^ Stenfors C, Ahlgren C, Yu H, Wedén M, Larsson LG, Ross SB. Effects of long-term administration of the 5-hydroxytryptamine1B receptor antagonist AR-A000002 to guinea pigs. Psychopharmacology (Berlin). 2004 Mar;172(3):333-40. PMID 14652708
- ^ Stenfors C, Hallerbäck T, Larsson LG, Wallsten C, Ross SB. Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002. Naunyn Schmiedebergs Archives of Pharmacology. 2004 Mar;369(3):330-7. PMID 14758468