Botulinski toksin B

(преусмерено са Botulinum toxin)

Botulinski toksin B je neurotoksin formiran fermentacijom of Clostridium botulinum tipa B.[1] Protein je nekovalentno vezan za hemaglutininske i nehemaglutininske proteine u neurotoksinskom kompleksu. Neurotoksinski kompleks se proizvodi procesom fermencaje i prečišćavanja putem serije koraka precipitacije i hromatografije.[2][3][4][5][6][7][8]

Botulinski toksin B
Klinički podaci
Prodajno imeMyobloc (Solstice Neurosciences), Neurobloc (Solstice Neurosciences)
Drugs.comtoxin.html Monografija
Način primeneIntramuscular
Identifikatori
CAS broj93384-44-2 ДаY
ATC kodNone
PubChemCID 5485225
DrugBankDB00042 ДаY

Reference

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  1. ^ Hanson, M.A., Stevens, R.C. (2000). „Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution”. Nat.Struct.Biol. 7: 687—692. PMID 10932255. 
  2. ^ Montecucco C, Molgo J: Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol. 2005 Jun;5(3):274-9. PMID 15907915
  3. ^ Brin MF, Lew MF, Adler CH, Comella CL, Factor SA, Jankovic J, O'Brien C, Murray JJ, Wallace JD, Willmer-Hulme A, Koller M: Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-resistant cervical dystonia. Neurology. 1999 Oct 22;53(7):1431-8. PMID 10534247
  4. ^ Shukla HD, Sharma SK: Clostridium botulinum: a bug with beauty and weapon. Crit Rev Microbiol. 2005;31(1):11-8. PMID 15839401
  5. ^ Eisenach JH, Atkinson JL, Fealey RD: Hyperhidrosis: evolving therapies for a well-established phenomenon. Mayo Clin Proc. 2005 May;80(5):657-66. PMID 15887434
  6. ^ Schurch B, Corcos J: Botulinum toxin injections for paediatric incontinence. Curr Opin Urol. 2005 Jul;15(4):264-7. PMID 15928517
  7. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  8. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 

Literatura

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Spoljašnje veze

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