CHST11

CHST11
Identifikatori
Alijasi	CHST11
Spoljašnji ID	OMIM: 610128 MGI: 1927166 HomoloGene: 56808 GeneCards: CHST11
Genska lokacija (miš)
Hr.	Chromosome 10 (mouse)
Kraj	83,031,734 bp
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• transferase activity; • sulfotransferase activity; • N-acetylgalactosamine 4-O-sulfotransferase activity; • N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; • chondroitin 4-sulfotransferase activity;
Cellular component	• Голџијев апарат; • мембрана; • Golgi membrane; • саставни део мембране;
Biological process	• embryonic skeletal system morphogenesis; • chondrocyte development; • embryonic digit morphogenesis; • негативно регулисање апоптотичког процеса; • negative regulation of transforming growth factor beta receptor signaling pathway; • post-embryonic development; • respiratory gaseous exchange by respiratory system; • cartilage development; • developmental growth; • regulation of cell population proliferation; • embryonic limb morphogenesis; • polysaccharide localization; • post-anal tail morphogenesis; • embryonic viscerocranium morphogenesis; • carbohydrate biosynthetic process; • chondroitin sulfate biosynthetic process; • chondroitin sulfate metabolic process; • Метаболизам угљених хидрата; • proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Ortolozi
	50515
	58250
	ENSG00000171310
	ENSMUSG00000034612
	Q9NPF2
	Q9JME2
	NM_018413; NM_001173982
	NM_021439
	NP_001167453; NP_060883; NP_060883.1
	NP_067414
	Wikidata
View/Edit Human	View/Edit Mouse

Ugljeno hidratna sulfotransferaza 11 (eng. Carbohydrate sulfotransferase 11) je enzim koji je kod ljudi kodiran istoimenim genom CHST11^[4]^[5], nalazi se na kratkom kraku hromozoma 12.^[6] Dužina polipeptidnog lanca je 352 aminokiselina, a molekulska težina 41 555.^[7].

Klinička relevantnost

Mutacije ovog gena su povezane sa osetljivošću na artrozu.^[8]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000034612 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (јун 2000). „Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family”. The Journal of Biological Chemistry. 275 (26): 20188—96. PMID 10781601. doi:10.1074/jbc.M002443200  .
^ „Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11”.
^ „HUGO Gene Nomenclature Commitee, HGNC:17422” (на језику: eng.). Архивирано из оригинала 3. 09. 2016. г. Приступљено 07. 06. 2024.
^ „UniProt, Q9NPF2” (на језику: англ.). Архивирано из оригинала 16. 01. 2017. г. Приступљено 07. 06. 2024.
^ Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, et al. (септембар 2012). „Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study”. Lancet. 380 (9844): 815—23. PMC 3443899  . PMID 22763110. doi:10.1016/S0140-6736(12)60681-3.

Literatura

Yamauchi S, Mita S, Matsubara T, Fukuta M, Habuchi H, Kimata K, Habuchi O (март 2000). „Molecular cloning and expression of chondroitin 4-sulfotransferase”. The Journal of Biological Chemistry. 275 (12): 8975—81. PMID 10722746. doi:10.1074/jbc.275.12.8975  .
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (март 2000). „Shotgun sequencing of the human transcriptome with ORF expressed sequence tags”. Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491—6. Bibcode:2000PNAS...97.3491D. PMC 16267  . PMID 10737800. doi:10.1073/pnas.97.7.3491  .
Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, Fukuta M, Kuroiwa A, Matsuda Y, Habuchi O (новембар 2000). „Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase”. Journal of Biochemistry. 128 (5): 763—70. PMID 11056388. doi:10.1093/oxfordjournals.jbchem.a022813.
Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (септембар 2003). „Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis”. The Journal of Biological Chemistry. 278 (38): 36115—27. PMID 12847091. doi:10.1074/jbc.M306044200  .
Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H, Haas OA, Chaganti RS (септембар 2004). „Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32)”. Oncogene. 23 (41): 6991—6. PMID 15273723. doi:10.1038/sj.onc.1207934  .
Yamada T, Ohtake S, Sato M, Habuchi O (децембар 2004). „Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues”. The Biochemical Journal. 384 (Pt 3): 567—75. PMC 1134142  . PMID 15324304. doi:10.1042/BJ20040965.
Yusa A, Kitajima K, Habuchi O (мај 2005). „N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1”. The Biochemical Journal. 388 (Pt 1): 115—21. PMC 1186699  . PMID 15628971. doi:10.1042/BJ20041573.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000034612 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10781601-4] Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (јун 2000). „Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family”. The Journal of Biological Chemistry. 275 (26): 20188—96. PMID 10781601. doi:10.1074/jbc.M002443200  .

[entrez-5] „Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11”.

[HGNC-6] „HUGO Gene Nomenclature Commitee, HGNC:17422” (на језику: eng.). Архивирано из оригинала 3. 09. 2016. г. Приступљено 07. 06. 2024.

[UniProt-7] „UniProt, Q9NPF2” (на језику: англ.). Архивирано из оригинала 16. 01. 2017. г. Приступљено 07. 06. 2024.

[8] Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, et al. (септембар 2012). „Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study”. Lancet. 380 (9844): 815—23. PMC 3443899  . PMID 22763110. doi:10.1016/S0140-6736(12)60681-3.

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