CHST5

CHST5
Identifikatori
Alijasi	CHST5
Spoljašnji ID	OMIM: 604817 HomoloGene: 69379 GeneCards: CHST5
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• transferase activity; • sulfotransferase activity; • N-acetylglucosamine 6-O-sulfotransferase activity;
Cellular component	• Golgi membrane; • Голџијев апарат; • intrinsic component of Golgi membrane; • мембрана; • саставни део мембране; • trans-Golgi network;
Biological process	• sulfur compound metabolic process; • protein sulfation; • keratan sulfate biosynthetic process; • N-acetylglucosamine metabolic process; • Метаболизам угљених хидрата;
	Sources:Amigo / QuickGO
Ortolozi
	23563
	n/a
	ENSG00000135702
	n/a
	Q9GZS9
	n/a
	NM_024533; NM_012126
	n/a
	NP_078809
	n/a
	Wikidata
View/Edit Human

Ugljeno hidratna sulfotransferaza 5 (eng. Carbohydrate sulfotransferase 5) je enzim koji je kod ljudi kodiran istoimenim genom CHST5^[2]^[3]^[4] , nalazi se na kratkom kraku 16 hromozoma.^[5] Dužina polipeptidnog lanca je 411 aminokiselina, a molekulska težina 46.161.^[6]

Reference

^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee JK, Bhakta S, Rosen SD, Hemmerich S (септембар 1999). „Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue”. Biochemical and Biophysical Research Communications. 263 (2): 543—9. PMID 10491328. doi:10.1006/bbrc.1999.1324.
^ Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (октобар 2000). „Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene”. Nature Genetics. 26 (2): 237—41. PMID 11017086. S2CID 25547752. doi:10.1038/79987.
^ „Entrez Gene: CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5”.
^ „HUGO Gene Nomenclature Commitee, HGNC:1971” (на језику: eng.). Приступљено 19. 09. 2017.
^ „UniProt, Q9GZS9” (на језику: eng.). Архивирано из оригинала 1. 1. 2017. г. Приступљено 07. 06. 2024.

Literatura

Bernstein HB, Compans RW (децембар 1992). „Sulfation of the human immunodeficiency virus envelope glycoprotein”. Journal of Virology. 66 (12): 6953—9. PMC 240329  . PMID 1433500. doi:10.1128/JVI.66.12.6953-6959.1992.
Shilatifard A, Merkle RK, Helland DE, Welles JL, Haseltine WA, Cummings RD (фебруар 1993). „Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine”. Journal of Virology. 67 (2): 943—52. PMC 237448  . PMID 8419650. doi:10.1128/JVI.67.2.943-952.1993.
Bartes A, Bhakta S, Hemmerich S (април 2001). „Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)”. Biochemical and Biophysical Research Communications. 282 (4): 928—33. PMID 11352640. doi:10.1006/bbrc.2001.4668.
Seko A, Nagata K, Yonezawa S, Yamashita K (јун 2002). „Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma”. Glycobiology. 12 (6): 379—88. PMID 12107080. doi:10.1093/glycob/12.6.379  .
Akama TO, Misra AK, Hindsgaul O, Fukuda MN (новембар 2002). „Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate”. The Journal of Biological Chemistry. 277 (45): 42505—13. PMID 12218059. doi:10.1074/jbc.M207412200  .
Lee JK, Bistrup A, van Zante A, Rosen SD (април 2003). „Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications”. Glycobiology. 13 (4): 245—54. PMID 12626414. doi:10.1093/glycob/cwg018.
de Graffenried CL, Bertozzi CR (октобар 2003). „Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis”. The Journal of Biological Chemistry. 278 (41): 40282—95. PMID 12855678. doi:10.1074/jbc.M304928200  .
Kitayama K, Hayashida Y, Nishida K, Akama TO (октобар 2007). „Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans”. The Journal of Biological Chemistry. 282 (41): 30085—96. PMID 17690104. doi:10.1074/jbc.M703695200  .

[1] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10491328-2] Lee JK, Bhakta S, Rosen SD, Hemmerich S (септембар 1999). „Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue”. Biochemical and Biophysical Research Communications. 263 (2): 543—9. PMID 10491328. doi:10.1006/bbrc.1999.1324.

[pmid11017086-3] Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (октобар 2000). „Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene”. Nature Genetics. 26 (2): 237—41. PMID 11017086. S2CID 25547752. doi:10.1038/79987.

[entrez-4] „Entrez Gene: CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5”.

[HGNC-5] „HUGO Gene Nomenclature Commitee, HGNC:1971” (на језику: eng.). Приступљено 19. 09. 2017.

[UniProt-6] „UniProt, Q9GZS9” (на језику: eng.). Архивирано из оригинала 1. 1. 2017. г. Приступљено 07. 06. 2024.

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