Kalikrein

Kalikreini su podgrupa serinskih proteaza, enzima koji imaju sposobnost razlaganja peptidnih veza u proteinima. Kod ljudi, kalikrein plazme^[1]^[2]^[3]^[4]^[5] (KLKB1) nema poznatih homologa, dok tkivne kalikreinu srodne peptidaze (KLKs) kodiraju familiju od petnaest blisko srodnih serinskih proteaza. Ti geni su locirani na hromozomu 19q13, i formiraju najveći kluster susednih proteaza u ljudskom genomu. Kalikreini su odgovorni za koordinaciju raznih fizioloških funkcija uključujući krvni pritisak, utečnjavanje semena i deskvamaciju kože.

Reference

^ Heimark, R.L. & Davie, E.W. (1981). „Bovine and human plasma prekallikrein”. Methods Enzymol. 80: 157—172. PMID 6918767.
^ McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. (1981). „Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates”. Biochemistry. 20: 7196—7206. PMID 6976185.
^ Silverberg, M. & Kaplan, A.P. (1988). „Prekallikrein”. Methods Enzymol. 163: 85—95. PMID 3237096.
^ Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. (1989). „The cDNA structure of rat plasma kallikrein”. DNA. 8: 563—574. PMID 2598771.
^ Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. (1989). „Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein”. Chem. Pharm. Bull. 37: 3108—3111. PMID 2534361.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Vidi još

Kalikrein plazme, enzim
Kalikrein renalnog tkiva, enzim

Spoljašnje veze

MEROPS onlajn baza podataka o peptidazama i njihovim inhibitorima: S01.212 Архивирано на сајту Wayback Machine (27. мај 2020)
Kallikreins на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Heimark, R.L. & Davie, E.W. (1981). „Bovine and human plasma prekallikrein”. Methods Enzymol. 80: 157—172. PMID 6918767.

[2] McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. (1981). „Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates”. Biochemistry. 20: 7196—7206. PMID 6976185.

[3] Silverberg, M. & Kaplan, A.P. (1988). „Prekallikrein”. Methods Enzymol. 163: 85—95. PMID 3237096.

[4] Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. (1989). „The cDNA structure of rat plasma kallikrein”. DNA. 8: 563—574. PMID 2598771.

[5] Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. (1989). „Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein”. Chem. Pharm. Bull. 37: 3108—3111. PMID 2534361.

[1]

[2]

[3]

[4]

[5]