RAS p21 proteinski aktivator 1

RAS p21 proteinski aktivator 1 ili RasGAP (aktivirajući protein Ras GTPaze), takođe poznat kao RASA1, je 120-kDa citosolni ljudski protein koji ima dve glavne aktivnosti:

  • Inakctivacija Ras proteina iz njegove aktivne GTP-vezane forme do njegove neaktivne GDP-vezane forme pojačavanjem endogene GTPazne Ras aktivnosti, preko njegovog C-terminalnog GAP domena
  • Mitogena transmisija signala u smeru daljih interakcionih partnera putemn njegovih N-terminalnih SH2-SH3-SH2 domena
RAS p21 proteinski aktivator (Protein aktivacije GTPaze) 1
PDB rendering based on 1wer.
Доступне структуре
1WER, 1WQ1, 2GQI, 2GSB, 2J05, 2J06, 2M51, 4FSS
Идентификатори
Симболи RASA1; CM-AVM; CMAVM; GAP; PKWS; RASA; RASGAP; p120GAP; p120RASGAP
Вањски ИД OMIM139150 MGI97860 HomoloGene2168 GeneCards: RASA1 Gene
Преглед РНК изражавања
PBB GE RASA1 210621 s at tn.png
PBB GE RASA1 202677 at tn.png
подаци
Ортолози
Врста Човек Миш
Ентрез 5921 218397
Eнсембл ENSG00000145715 ENSMUSG00000021549
UниПрот P20936 E9PYG6
Реф. Секв. (иРНК) NM_002890 NM_145452
Реф. Секв. (протеин) NP_002881 NP_663427
Локација (УЦСЦ) Chr 5:
86.56 - 86.69 Mb
Chr 13:
85.21 - 85.29 Mb
ПубМед претрага [1] [2]

Protein kodiran ovim genom je lociran u citoplazmi i deo je GAP1 familije GTPazno-aktiviranih proteina. Ovaj genski produkt stimuliše GTPaznu aktivnost normalnog RAS p21, ali ne i njegovog onkogenog pandana. Delujući kao supresor RAS funkcije, ovaj protein pojačava slabu unutrašnju GTPaznu aktivnost RAS proteina, što dovodi do inaktiviranje GDP-vezane forme RAS-a, čime pospešuje kontrolu ćelijske proliferacije i diferencijacije. Mutacije koje dovode do promena u mestima vezivanja ovog proteina su vezane za bazalne ćelijske kacinome. Alternativnim splajsovanjem se formiraju dve izoforme, pri čemu kraća izoforma, kojoj nedostaje N-terminusni hidrofobni region zadržava aktivnost. Ona je izobilno izražena u materičnim, ali ne i odraslim tkivima.[1]

DomeniУреди

RasGAP sadrži jedan SH3 domen i dva SH2 domena, PH domen, i GAP domen.

InterakcijeУреди

RAS p21 proteinski aktivator 1 formira interakcije sa:

iRNK može da formira interakcije sa Mir-132 mikroRNK. Ovaj protein učestvuje u angiogenezi.[28]

Baza podataka bolestiУреди

ReferenceУреди

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LiteraturaУреди

  • Tocque B; Delumeau I; Parker F; et al. (1997). „Ras-GTPase activating protein (GAP): a putative effector for Ras”. Cell. Signal. 9 (2): 153—8. PMID 9113414. doi:10.1016/S0898-6568(96)00135-0. 
  • Boon LM, Mulliken JB, Vikkula M (2005). „RASA1: variable phenotype with capillary and arteriovenous malformations”. Curr. Opin. Genet. Dev. 15 (3): 265—9. PMID 15917201. doi:10.1016/j.gde.2005.03.004. 

Spoljašnje vezeУреди