RFC2
Репликациони фактор C, подјединица 2 је протеин који је код људи кодиран RFC2 геном.[1][2][3]
| Replikacioni faktor C (aktivator 1) 2, 40kDa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Идентификатори | |||||||||||
| Симболи | RFC2; A1; RFC40 | ||||||||||
| Вањски ИД | OMIM: 600404 MGI: 1341868 HomoloGene: 6885 GeneCards: RFC2 Gene | ||||||||||
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| Преглед РНК изражавања | |||||||||||
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| подаци | |||||||||||
| Ортолози | |||||||||||
| Врста | Човек | Миш | |||||||||
| Ентрез | 5982 | 19718 | |||||||||
| Eнсембл | ENSG00000049541 | ENSMUSG00000023104 | |||||||||
| UниПрот | P35250 | Q9WUK4 | |||||||||
| Реф. Секв. (иРНК) | NM_002914 | NM_020022 | |||||||||
| Реф. Секв. (протеин) | NP_002905 | NP_064406 | |||||||||
| Локација (УЦСЦ) |
Chr 7: 73.65 - 73.67 Mb |
Chr 5: 134.58 - 134.6 Mb | |||||||||
| ПубМед претрага | [1] | [2] | |||||||||
За елонгацију прајмираног ДНК шаблона посредством ДНК полимеразе делта и епсилон неопходни су помоћни протеини, пролиферишући ћелијски нуклеарни антиген (PCNA) и репликациони фактор Ц (РФЦ). RFC, такође познат као активатор 1, је протеински комплекс који се састоји од пет подјединица са 145, 40, 38, 37, и 36.5 кД. Овај ген кодира 40 кД подјединицу, за коју је показано да је одговорна за АТП везивање. Брисање овог гена је асоцирано са Вилијамсову синдромом. Алтернативно сплајсоване транскриптне варијанте кодирају дистинктне изоформе[3].
Интеракције
уредиRFC2 формира интеракције са BRD4,[4] CHTF18,[5][6] PCNA,[7][8][9] RFC4[7][10] и RFC5.[7][10]
Референце
уреди- ^ Chen M, Pan ZQ, Hurwitz J (мај 1992). „Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells”. Proc Natl Acad Sci U S A. 89 (7): 2516—20. PMC 48692
. PMID 1313560. doi:10.1073/pnas.89.7.2516.
- ^ Okumura K; Nogami M; Taguchi H; Dean FB; Chen M; Pan ZQ; Hurwitz J; Shiratori A; Murakami Y; Ozawa K; et al. (јул 1995). „Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23”. Genomics. 25 (1): 274—8. PMID 7774928. doi:10.1016/0888-7543(95)80135-9.
- ^ а б „Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa”.
- ^ Maruyama, Tetsuo; Farina Andrea; et al. (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase”. Mol. Cell. Biol. United States. 22 (18): 6509—20. ISSN 0270-7306. PMC 135621 . PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.
- ^ Bermudez, Vladimir P; Maniwa Yoshimasa; et al. (2003). „The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (18): 10237—42. ISSN 0027-8424. PMC 193545 . PMID 12930902. doi:10.1073/pnas.1434308100.
- ^ Merkle, Carolin J; Karnitz Larry M; et al. (2003). „Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment”. J. Biol. Chem. United States. 278 (32): 30051—6. ISSN 0021-9258. PMID 12766176. doi:10.1074/jbc.M211591200.
- ^ а б в Cai, J; Gibbs E, Uhlmann F; et al. (1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme”. J. Biol. Chem. UNITED STATES. 272 (30): 18974—81. ISSN 0021-9258. PMID 9228079. doi:10.1074/jbc.272.30.18974.
- ^ Pan, Z Q; Chen M; Hurwitz J (јануар 1993). „The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 90 (1): 6—10. ISSN 0027-8424. PMC 45588 . PMID 8093561. doi:10.1073/pnas.90.1.6.
- ^ Ohta, Satoshi; Shiomi Yasushi; et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. United States. 277 (43): 40362—7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.
- ^ а б Cai, J; Yao N; et al. (1998). „ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 95 (20): 11607—12. ISSN 0027-8424. PMC 21688 . PMID 9751713. doi:10.1073/pnas.95.20.11607.
Литература
уреди- Pan ZQ, Chen M, Hurwitz J (1993). „The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis.”. Proc. Natl. Acad. Sci. U.S.A. 90 (1): 6—10. PMC 45588 . PMID 8093561. doi:10.1073/pnas.90.1.6.
- Peoples R; Perez-Jurado L; Wang YK; et al. (1996). „The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion.”. Am. J. Hum. Genet. 58 (6): 1370—3. PMC 1915059 . PMID 8651315.
- Uhlmann F; Cai J; Flores-Rozas H; et al. (1996). „In vitro reconstitution of human replication factor C from its five subunits.”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521—6. PMC 39056 . PMID 8692848. doi:10.1073/pnas.93.13.6521.
- Osborne LR; Martindale D; Scherer SW; et al. (1997). „Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.”. Genomics. 36 (2): 328—36. PMID 8812460. doi:10.1006/geno.1996.0469.
- Cujec TP; Cho H; Maldonado E; et al. (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.”. Mol. Cell. Biol. 17 (4): 1817—23. PMC 232028 . PMID 9121429.
- Cai J; Gibbs E; Uhlmann F; et al. (1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme.”. J. Biol. Chem. 272 (30): 18974—81. PMID 9228079. doi:10.1074/jbc.272.30.18974.
- Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity.”. J. Biol. Chem. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979.
- Zhang G; Gibbs E; Kelman Z; et al. (1999). „Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen.”. Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869—74. PMC 26703 . PMID 10051561. doi:10.1073/pnas.96.5.1869.
- Wang Y; Cortez D; Yazdi P; et al. (2000). „BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.”. Genes Dev. 14 (8): 927—39. PMC 316544 . PMID 10783165.
- Martindale DW; Wilson MD; Wang D; et al. (2000). „Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.”. Mamm. Genome. 11 (10): 890—8. PMID 11003705. doi:10.1007/s003350010166.
- Griffith JD, Lindsey-Boltz LA, Sancar A (2002). „Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.”. J. Biol. Chem. 277 (18): 15233—6. PMID 11907025. doi:10.1074/jbc.C200129200.
- Nieborowska-Skorska M; Hoser G; Kossev P; et al. (2002). „Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.”. Blood. 99 (12): 4531—9. PMID 12036885. doi:10.1182/blood.V99.12.4531.
- Ohta S; Shiomi Y; Sugimoto K; et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.
- Maruyama T; Farina A; Dey A; et al. (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase.”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621 . PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (2003). „Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.”. J. Biol. Chem. 278 (32): 30051—6. PMID 12766176. doi:10.1074/jbc.M211591200.
- Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7.”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.
- Bermudez VP; Maniwa Y; Tappin I; et al. (2003). „The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.”. Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10237—42. PMC 193545 . PMID 12930902. doi:10.1073/pnas.1434308100.