Википедија

Receptor epidermalnog faktora rasta

Receptor epidermalnog faktora rasta (EGFR; ErbB-1; HER1 kod ljudi) je receptor ćelijske površine članova familije epidermalnih faktora rasta (EGF-familija) ekstracelularnih proteina liganda.[1]

epidermal growth factor receptor
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Receptor epidermalnog faktora rasta je član ErbB familije receptora, subfamilije sa četiri blisko srodna receptora tirozinske kinaze: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) i Her 4 (ErbB-4). Mutacije koje utiču na izražavanje ili aktivnost EGFR mogu da dovedu do kancera.[2]

Epidermalni faktor rasta i njegov receptor je otkrio Stanli Kohen na Vanderbilt univerzitetu. Kohen je podelio Nobelovu nagradu za fiziologiju ili medicinu 1986. sa Ritom Levi-Montalcini za njihovo otkriće faktora rasta.

Patologija уреди

Mutacije zametka уреди

  • V843I : Predispozicija za rak pluća[3]

Interakcija уреди

Poznato je da receptor epidermalnog faktora rasta formira interakcije sa:

Reference уреди

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Literatura уреди

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Spoljašnje veze уреди

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