Википедија

Receptor retinoinske kiseline beta

Receptor retinoinske kiseline beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor encoded by the RARB gene.[1]

Receptor retinoinske kiseline, beta
PDB slika je bazirana na 1xap.
Dostupne strukture
1dsz​, 1hra​, 1xap​, 1xdk​
Identifikatori
Simboli RARB; HAP; NR1B2; RRB2
Vanjski ID OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5915 218772
Ensembl ENSG00000077092 ENSMUSG00000017491
UniProt P10826 Q8K1P6
RefSeq (mRNA) NM_000965 NM_011243
RefSeq (protein) NP_000956 NP_035373
Lokacija (UCSC) Chr 3:
25.19 - 25.61 Mb		 Chr 14:
15.22 - 15.61 Mb
PubMed pretraga [1] [2]

Ovaj gen kodira receptor retinoinske kiseline beta, koji je član tiroid-steroid hormon receptorske super-familije nuklearnih transkripcionih regulatora. Ovaj receptor je lokalizovan u citoplazmi i u sub-nuklearnim kompartmanima. On vezuje retinoinsku kiselinu, biološki aktivnu formu vitamina A čime posreduje ćelijsku signalizaciju embrionske morfogene, ćelijski rast i diferencijaciju. Smatra se da ovaj protein ograničava rast mnogih ćelijskih tipova putem regulacije izražavanja gena. Ovaj gen je prvo identifikovan kod hepatocelularnih karcinoma, kod kojih se on nalazi pored integracionog mesta hepatitis B virusa. Ovaj gen izražava najmanje dve transkriptne varijante; jedan dodatni transkript je bio opisan, ali puna dužina njegovog proteina nije bila određena.[1]

Interakcije уреди

Pokazano je da receptor retinoinske kiseline beta ima interakciju sa Nuklearni receptor srodnim 1 proteinom.[2]

Reference уреди

  1. ^ а б „Entrez Gene: RARB retinoic acid receptor, beta”. 
  2. ^ Perlmann, T; Jansson, L. (1995). „A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1”. Genes Dev. UNITED STATES. 9 (7): 769—82. ISSN 0890-9369. PMID 7705655. 

Literatura уреди

  • Dejean A, de Thé H (1990). „Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma.”. Mol. Biol. Med. 7 (3): 213—22. PMID 2170809. 
  • Sun, S. Y. (2004). „Retinoic acid receptor beta and colon cancer.”. Cancer Biol. Ther. 3 (1): 87—8. PMID 14726690. 
  • Saba N, Jain S, Khuri F (2004). „Chemoprevention in lung cancer.”. Current problems in cancer. 28 (5): 287—306. PMID 15375805. doi:10.1016/j.currproblcancer.2004.05.005. 
  • Klein, O.; Y, Grignon; Civit, T.; et al. (2006). „[Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal cells. 48 tumors]”. Neuro-Chirurgie. 51 (3-4 Pt 1): 147—54. PMID 16389900. 
  • Katahira, M.; Knegtel, R. M.; Boelens, R.; et al. (1992). „Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements.”. Biochemistry. 31 (28): 6474—80. PMID 1321662. doi:10.1021/bi00143a017. 
  • Berrodin, T. J.; MS, Marks; Ozato, K.; et al. (1992). „Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.”. Mol. Endocrinol. 6 (9): 1468—78. PMID 1331778. doi:10.1210/me.6.9.1468. 
  • van der Leede BJ, Folkers GE, Kruyt FA, van der Saag PT (1992). „Genomic organization of the human retinoic acid receptor beta 2.”. Biochem. Biophys. Res. Commun. 188 (2): 695—702. PMID 1332705. doi:10.1016/0006-291X(92)91112-4. 
  • Prentice A, Matthews CJ, Thomas EJ, Redfern CP (1992). „The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid.”. Hum. Reprod. 7 (5): 692—700. PMID 1379266. 
  • Shen, S.; Kruyt, F. A.; den Hertog J; et al. (1992). „Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness.”. DNA Seq. 2 (2): 111—9. PMID 1663808. doi:10.3109/10425179109039679. 
  • de Thé H; Vivanco-Ruiz MM; Tiollais, P.; et al. (1990). „Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene.”. Nature. 343 (6254): 177—80. PMID 2153268. doi:10.1038/343177a0. 
  • Hoffmann, B.; Lehmann, J. M.; XK, Zhang; et al. (1991). „A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter.”. Mol. Endocrinol. 4 (11): 1727—36. PMID 2177841. doi:10.1210/mend-4-11-1727. 
  • de Thé H, Marchio A, Tiollais P, Dejean A (1988). „A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma.”. Nature. 330 (6149): 667—70. PMID 2825037. doi:10.1038/330667a0. 
  • Brand, N.; M, Petkovich; Krust, A.; et al. (1988). „Identification of a second human retinoic acid receptor.”. Nature. 332 (6167): 850—3. PMID 2833708. doi:10.1038/332850a0. 
  • Benbrook D, Lernhardt E, Pfahl M (1988). „A new retinoic acid receptor identified from a hepatocellular carcinoma.”. Nature. 333 (6174): 669—72. PMID 2836738. doi:10.1038/333669a0. 
  • Mattei, M. G.; de Thé H; Mattei, J. F.; et al. (1988). „Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3.”. Hum. Genet. 80 (2): 189—90. PMID 2844650. doi:10.1007/BF00702867. 
  • Dejean A, Bougueleret L, Grzeschik KH, Tiollais P (1986). „Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma.”. Nature. 322 (6074): 70—2. PMID 3014347. doi:10.1038/322070a0. 
  • Si SP, Tsou HC, Lee X, Peacocke M (1995). „Effect of cellular senescence and retinoic acid on the expression of cellular retinoic acid binding proteins in skin fibroblasts.”. Exp. Cell Res. 219 (1): 243—8. PMID 7628539. doi:10.1006/excr.1995.1224. 
  • Houle, B.; M, Pelletier; Wu, J.; et al. (1994). „Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines.”. Cancer Res. 54 (2): 365—9. PMID 8275470. 
  • Knegtel, R. M.; Katahira, M.; Schilthuis, J. G.; et al. (1993). „The solution structure of the human retinoic acid receptor-beta DNA-binding domain.”. J. Biomol. NMR. 3 (1): 1—17. PMID 8383553. doi:10.1007/BF00242472. 

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