Transmembranski domen ABC transportera

Transmembranski domen ABC transportera je glavna transmembranska strukturna jedinica ATP-vezujućeg kasetnog transportera koja se sastoji od šest transmembranskih domena. Mnogi članovi ABC transporterske familije (Pfam PF00005) imaju dva takva regiona.[1][2][3][4][5][6]

Transmembranski domen ABC transportera
Идентификатори
Симбол ABC_membrane
Пфам PF00664
ИнтерПро IPR001140
ПРОСИТЕ PDOC00364
СКОП 1pf4
ТЦДБ 3.A.1
ОПМ фамилија Eksporteri lipida/lekova 1.1.10.03. Eksporteri lipida/lekova
ОПМ протеин 2hyd

PotfamilijeУреди

Ljudski proteini koji sadrže ovaj domenУреди

ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC13; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; CFTR; TAP1; TAP2; TAPL;

ReferenceУреди

  1. ^ Kerr ID (2002). „Structure and association of ATP-binding cassette transporter nucleotide-binding domains”. Biochim. Biophys. Acta. 1561 (1): 47—64. PMID 11988180. doi:10.1016/s0304-4157(01)00008-9. 
  2. ^ Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K (2001). „Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter”. Structure. 9 (7): 571—86. PMID 11470432. doi:10.1016/S0969-2126(01)00617-7. 
  3. ^ Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ (2001). „The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter”. J. Biol. Chem. 276 (34): 32313—21. PMID 11402022. doi:10.1074/jbc.M100758200. 
  4. ^ Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF (1998). „Crystal structure of the ATP-binding subunit of an ABC transporter”. Nature. 396 (6712): 703—707. PMID 9872322. doi:10.1038/25393. 
  5. ^ Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C (2000). „Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis”. EMBO J. 19 (22): 5951—61. PMC 305842 . PMID 11080142. doi:10.1093/emboj/19.22.5951. 
  6. ^ Wiley DC, Gaudet R (2001). „Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing”. EMBO J. 20 (17): 4964—72. PMC 125601 . PMID 11532960. doi:10.1093/emboj/20.17.4964. 

Spoljapnje vezeУреди