ГНАQ
GNAQ, Guanin nukleotid-vezujući protein G(q), podjedinica alfa, je protein koji je kod ljudi kodiran GNAQ genom.[1]
Guanin nukleotid-vezujući proteini su familija heterotrimernih proteina koji se uparuju sa proteinima ćelijske površine, 7-TM domenskim receptorima, i posreduju intracelularnu signalizaciju. Aktivacija receptora katalizuje izmenu GDP za GTP. GDP je vezan za neaktivnu G protein alfa podedinicu. Vezivanje agonista dovodi do konformacione promene i disocijacije kompleksa. G protein alfa i beta-gama podjedinice imaju sposobnost regulacije niza celularnih efektora. Aktivacija se okončava GTPazom specifičnom za G-alfa podjedinicu. G-alfa-q podjedinica je jedan od heterotrimernih GTP-vezujućih proteina koji posreduje stimulaciju fosfolipaze C-beta (MIM 600230).[2]
Interakcije
уредиZa GNAQ je bilo pokazano da interaguje sa natrijum-vodonik antiporterom 3, regulator 1,[3] RIC8A,[4][5] RGS16,[6] beta adrenergički receptor kinazom,[7] RGS4[6][8] i Brutonovom tirozinskom kinazom.[9]
Reference
уреди- ^ Dong Q, Shenker A, Way J, Haddad BR, Lin K, Hughes MR, McBride OW, Spiegel AM, Battey J (1997). „Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene”. Genomics. 30 (3): 470—75. PMID 8825633. doi:10.1006/geno.1995.1267.
- ^ „Entrez Gene: GNAQ guanine nucleotide binding protein (G protein), q polypeptide”.
- ^ Rochdi, Moulay Driss; Valérie, Watier; et al. (2002). „Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)”. J. Biol. Chem. United States. 277 (43): 40751—9. ISSN 0021-9258. PMID 12193606. doi:10.1074/jbc.M207910200.
- ^ Klattenhoff, Carla; Martín, Montecino; et al. (2003). „Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol”. J. Cell. Physiol. United States. 195 (2): 151—7. ISSN 0021-9541. PMID 12652642. doi:10.1002/jcp.10300.
- ^ Tall, Gregory G.; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200.
- ^ а б
- ^ Day, Peter W.; Carman Christopher V; et al. (2003). „Differential interaction of GRK2 with members of the G alpha q family”. Biochemistry. United States. 42 (30): 9176—84. ISSN 0006-2960. PMID 12885252. doi:10.1021/bi034442.
- ^ Druey, K M.; Sullivan B M; et al. (1998). „Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane”. J. Biol. Chem. UNITED STATES. 273 (29): 18405—10. ISSN 0021-9258. PMID 9660808. doi:10.1074/jbc.273.29.18405.
- ^ Ma, Y C.; Huang X Y (1998). „Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 95 (21): 12197—201. ISSN 0027-8424. PMC 22808 . PMID 9770463. doi:10.1073/pnas.95.21.12197.
Literatura
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- J, Gabbeta; X, Yang; MA, Kowalska; et al. (1997). „Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses.”. Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8750—5. PMC 23110 . PMID 9238049. doi:10.1073/pnas.94.16.8750.