Interleukin 12B

Interleukin 12B (stimulacioni faktor 2 prirodnih ubica ćelija, faktor sazrevanja 2 citotoksičnih limfocita, p40)
Interleukin 12B (stimulacioni faktor 2 prirodnih ubica ćelija, faktor sazrevanja 2 citotoksičnih limfocita, p40)
	PDB prikaz baziran na 1f42.
Dostupne strukture
	1f42, 1f45
Identifikatori
Simboli	IL12B; CLMF; CLMF2; IL-12B; NKSF; NKSF2
Vanjski ID	OMIM: 161561 MGI: 96540 HomoloGene: 1648 GeneCards: IL12B Gene
Ontologija gena
Molekulska funkcija	• signal prenosnička aktivnost; • hematopoetin/interferon-klasa (D200-domen) citokin receptorska aktivnost; • citokinska aktivnost; • vezivanje za interleukin-12 receptor; • vezivanje za proteine; • vezivanje za interleukin-12 alfa podjedinicu; • proteinska homodimerizaciona aktivnost;
Ćelijska komponenta	• ekstracelularni region; • membrana;
Biološki proces	• prenos signala vezan za receptore na ćelijskoj porvršini; • antimikrobni respons glodara; • aktivacija prirodnih ubica ćelija; • regulacije biosintetičkog procesa citokina; • T-pomoćni 1 tip imunski respons; • diferencijacija T-pomoćnih ćelija; • interferon-gama biosintetički proces; • pozitivna regulacija diferencijacije T ćelija; • pozitivna regulacija interfero-gama biosintetičkog procesa;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	3593
Ensembl	ENSG00000113302
UniProt	P29460
Ref. Sekv. (iRNK)	NM_002187
Ref. Sekv. (protein)	NP_002178
Lokacija (UCSC)	Chr 5:; 158.67 - 158.69 Mb
PubMed pretraga	[1]

Interleukin 12 podjedinica beta (isto poznat kao stimulacioni faktor 2 prirodnih ubica ćelija, ili faktor sazrevanja 2 citotoksičnih limfocita, p40) (ljudski gen IL12B) je podjedinica ljudskog interleukina 12.

Ovaj gen kodira podjedinicu interleukina 12, citokina koji dejstvuje na T i prirodni ubica ćelijama, i ima dugačak niz bioloških aktivnosti. Interleukin 12 je disulfidno-vezan heterodimer koji se sastoji od 40 kD podjedinice koja je slična citokin receptoru i kodirana ovim genom, i 35 kD podjedinice kodirane IL12A genom. Ovaj citokin je izražen u aktiviranim makrofagama koje služe kao esencijalni pobuđivač razvoja Th1 ćelija.^[1] Za ovaj citokin je nađeno da je važan za održavanje dovoljnog broja memorijskih/efektorskih Th1 ćelija čime posreduje dugoročnu zaštitu od intracelularnih patogena. Pre-izražavanje ovog gena je primećeno u centralnom nervnom sistemu pacijenata sa multiplom sklerozom (MS), što sugerira da ovaj citokin igra ulogu u patogenezi bolesti. Promotor gen polimorfizam ovog gena se zna da je asociran sa ozbiljnošću astme kod dece.^[2]^[3]

Interakcije

Interleukin-12 podjedinica beta je pokazan da ostvaruje interakciju sa interleukinom 23.^[4]

Reference

^ Thomas J. Kindt; Richard A. Goldsby; Barbara Anne Osborne; Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1429202114.
^ „Entrez Gene: IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)”. Pristupljeno 1. 7. 2018.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ Oppmann, B (2000). Lesley R, Blom B, Timans J C, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams J S, Moore K W, Rennick D, de Waal-Malefyt R, Hannum C, Bazan J F, Kastelein R A. „Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12”. Immunity. UNITED STATES. 13 (5): 715—25. ISSN 1074-7613. PMID 11114383. Nepoznati parametar |quotes= ignorisan (pomoć); |access-date= zahteva |url= (pomoć)

Literatura

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Abdi, K. (2002). „IL-12: the role of p40 versus p75.”. Scand. J. Immunol. 56 (1): 1—11. PMID 12100467. doi:10.1046/j.1365-3083.2002.01101.x.
Sieburth, D.; Jabs EW; Warrington JA (1992). „Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.”. Genomics. 14 (1): 59—62. PMID 1358798. doi:10.1016/S0888-7543(05)80283-6.
Wolf, S. F.; Temple PA; Kobayashi M (1991). „Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.”. J. Immunol. 146 (9): 3074—81. PMID 1673147.
Gubler, U.; Chua AO; Schoenhaut DS (1991). „Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.”. Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4143—7. PMID 1674604. doi:10.1073/pnas.88.10.4143.
Gearing DP, Cosman D (1991). „Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor.”. Cell. 66 (1): 9—10. PMID 2070420. doi:10.1016/0092-8674(91)90131-H.
Stern, A. S.; Podlaski FJ; Hulmes JD (1990). „Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.”. Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6808—12. PMID 2204066. doi:10.1073/pnas.87.17.6808.
Aragane, Y.; Riemann H; Bhardwaj RS (1995). „IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines.”. J. Immunol. 153 (12): 5366—72. PMID 7527439.
Ling, P.; Gately MK; Gubler U (1995). „Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.”. J. Immunol. 154 (1): 116—27. PMID 7527811.
Murphy, T. L.; Cleveland MG; Kulesza P (1995). „Regulation of interleukin 12 p40 expression through an NF-kappa B half-site.”. Mol. Cell. Biol. 15 (10): 5258—67. PMID 7565674.
Sharma V, Knobloch TJ, Benjamin D (1995). „Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines.”. Biochem. Biophys. Res. Commun. 208 (2): 704—13. PMID 7695626. doi:10.1006/bbrc.1995.1395.
Warrington JA, Bengtsson U (1995). „High-resolution physical mapping of human 5q31-q33 using three methods: radiation hybrid mapping, interphase fluorescence in situ hybridization, and pulsed-field gel electrophoresis.”. Genomics. 24 (2): 395—8. PMID 7698768. doi:10.1006/geno.1994.1636.
D'Andrea A; Ma X; Aste-Amezaga M (1995). „Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.”. J. Exp. Med. 181 (2): 537—46. PMID 7836910. doi:10.1084/jem.181.2.537.
Gillessen, S.; Carvajal D; Ling P (1995). „Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist.”. Eur. J. Immunol. 25 (1): 200—6. PMID 7843232. doi:10.1002/eji.1830250133.
Radrizzani, M.; Accornero P; Amidei A (1995). „IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation.”. Cell. Immunol. 161 (1): 14—21. PMID 7867080. doi:10.1006/cimm.1995.1003.
X, M. a..; Chow JM; Gri G (1996). „The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.”. J. Exp. Med. 183 (1): 147—57. PMID 8551218. doi:10.1084/jem.183.1.147.
Fantuzzi, L.; Gessani S; Borghi P (1996). „Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion.”. J. Virol. 70 (6): 4121—4. PMID 8648753.
Cella, M.; Scheidegger D; Palmer-Lehmann K (1996). „Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.”. J. Exp. Med. 184 (2): 747—52. PMID 8760829. doi:10.1084/jem.184.2.747.
Kato, K.; Shimozato O; Hoshi K (1996). „Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection.”. Proc. Natl. Acad. Sci. U.S.A. 93 (17): 9085—9. PMID 8799158. doi:10.1073/pnas.93.17.9085.
Taoufik, Y.; Lantz O; Wallon C (1997). „Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect.”. Blood. 89 (8): 2842—8. PMID 9108403.

Spoljašnje veze

Interleukin-12B na US National Library of Medicine Medical Subject Headings (MeSH)

[KubyImmunology6th-1] Thomas J. Kindt; Richard A. Goldsby; Barbara Anne Osborne; Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1429202114.

[2] „Entrez Gene: IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)”. Pristupljeno 1. 7. 2018.

[3] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[pmid11114383-4] Oppmann, B (2000). Lesley R, Blom B, Timans J C, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams J S, Moore K W, Rennick D, de Waal-Malefyt R, Hannum C, Bazan J F, Kastelein R A. „Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12”. Immunity. UNITED STATES. 13 (5): 715—25. ISSN 1074-7613. PMID 11114383. Nepoznati parametar |quotes= ignorisan (pomoć); |access-date= zahteva |url= (pomoć)

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