Faktor rasta hepatocita

Faktor rasta hepatocita (hepapoietin A)
Faktor rasta hepatocita (hepapoietin A)
	PDB prikaz baziran na 1bht.
Dostupne strukture
	1bht, 1gmn, 1gmo, 1gp9, 1nk1, 1shy, 1si5, 2hgf
Identifikatori
Simboli	HGF; F-TCF; HGFB; HPTA; SF
Vanjski ID	OMIM: 142409 MGI: 96079 HomoloGene: 503 GeneCards: HGF Gene
Ontologija gena
Molekularna funkcija	• aktivnost serinske endopeptidaze; • vezivanje kalcijum jona; • proteinsko vezivanje; • aktivnost faktora rasta;
Celularna komponenta	• celularna komponenta;
Biološki proces	• aktivacija MAPK aktivnosti; • celularna morfogeneza; • proteoliza; • anti-apoptoza; • mitoza; • koagulacija krvi; • receptorski signalni put hepatocitnog faktora rasta; • mioblastna proliferacija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	3082
Ensembl	ENSG00000019991
UniProt	P14210
RefSeq (mRNA)	NM_000601
RefSeq (protein)	NP_000592
Lokacija (UCSC)	Chr 7:; 81.17 - 81.24 Mb
PubMed pretraga	[1]

Faktor rasta hepatocita (HGF/SF) je morfogeni faktor koji utiče na parakrini ćelijski rast i motilitet. Njega izlučuju mezenhimalne ćelije. On prvenstveno deluje na epitelne i endotelne ćelije, ali i na hematopoietske progenitorne ćelije. Pokazano je da ima značajnu ulogu u embrionskom razvoju organa, u regeneraciji organa kod odraslih osoba i zarastanju rana.^[1]

Faktor rasta hepatocita reguliše ćelijski rast, ćelijsku mobilnost i morfogenezu putem aktiviranja signalne kaskade tirozinskih kinaza nakon vezivanja za proto-onkogeni c-Met receptor. Faktor rasta hepatocita izlučen iz mezenhimalnih stem ćelija dejstvuje kao multi-funkcionalni citokin. Njegova sposobnost da stimuliše mitogenezu i ćelijsku motilnost daje mu centralnu ulogu u angiogenezi, tumorogenezi, i regeneraciji tkiva. On se izlučuje kao neaktivni polipeptid, koga presecaju serinske proteaze u 69-kDa alfa-lanac i 34-kDa beta-lanac. Disulfidna veza između alfa i beta lanaca proizvodi aktivni, heterodimerni molekul. Ovaj protein pripada plazminogen potfamiliji S1 peptidaza, ali nema primetnu proteaznu aktivnost. Alternativno splajsovanje ovog gene proizvodi višestruke transkriptne varijante koje kodiraju razne izoforme.^[2]

Interakcije

Za faktor rasta hepatocita je pokazano da interaguje sa C-Met.^[3]^[4]

Vidi još

Faktor rasta
Receptor faktora rasta hepatocita (HGFR)

Reference

^ Gallagher, J.T.; Lyon, M. (2000). „Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens”. Ур.: Iozzo, M. V. Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York. стр. 27–59.
^ „Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)”.
^ Comoglio, P M (1993). „Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells”. EXS. SWITZERLAND. 65: 131—65. ISSN 1023-294X. PMID 8380735.
^ Naldini, L; Weidner K M; et al. (1991). „Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor”. EMBO J. ENGLAND. 10 (10): 2867—78. ISSN 0261-4189. PMC 452997  . PMID 1655405.

Literatura

Nakamura T (1992). „Structure and function of hepatocyte growth factor.”. Prog. Growth Factor Res. 3 (1): 67—85. PMID 1838014. doi:10.1016/0955-2235(91)90014-U.
Ware LB, Matthay MA (2002). „Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair.”. Am. J. Physiol. Lung Cell Mol. Physiol. 282 (5): L924—40. PMID 11943656. doi:10.1152/ajplung.00439.2001.
Funakoshi H, Nakamura T (2003). „Hepatocyte growth factor: from diagnosis to clinical applications.”. Clin. Chim. Acta. 327 (1-2): 1—23. PMID 12482615. doi:10.1016/S0009-8981(02)00302-9.
Skibinski G (2004). „The role of hepatocyte growth factor/c-met interactions in the immune system.”. Arch. Immunol. Ther. Exp. (Warsz.). 51 (5): 277—82. PMID 14626426.
Kalluri R, Neilson EG (2004). „Epithelial-mesenchymal transition and its implications for fibrosis.”. J. Clin. Invest. 112 (12): 1776—84. PMC 297008  . PMID 14679171. doi:10.1172/JCI200320530.
Hurle RA; Davies G; Parr C; et al. (2006). „Hepatocyte growth factor/scatter factor and prostate cancer: a review.”. Histol. Histopathol. 20 (4): 1339—49. PMID 16136515.
Kemp LE, Mulloy B, Gherardi E (2006). „Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.”. Biochem. Soc. Trans. 34 (Pt 3): 414—7. PMID 16709175. doi:10.1042/BST0340414.
Gallagher, J.T.; Lyon, M. (2000). „Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens”. Ур.: Iozzo, M. V. Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York. стр. 27–59.

Spoljašnje veze

Hepatocyte+growth+factor на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Gallagher, J.T.; Lyon, M. (2000). „Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens”. Ур.: Iozzo, M. V. Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York. стр. 27–59.

[2] „Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)”.

[pmid8380735-3] Comoglio, P M (1993). „Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells”. EXS. SWITZERLAND. 65: 131—65. ISSN 1023-294X. PMID 8380735.

[pmid1655405-4] Naldini, L; Weidner K M; et al. (1991). „Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor”. EMBO J. ENGLAND. 10 (10): 2867—78. ISSN 0261-4189. PMC 452997  . PMID 1655405.

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