5-MeO-NBpBrT
5-MeO-NBpBrT (5-Metoksi-N-(4-bromobenzil)triptamin) je lek koji deluje kao antagonist za 5-HT2A receptor,[1] koji je sto puta selektivniji za taj receptor u odnosu na blisko srodni 5-HT2C receptor.[2][3][4]
IUPAC ime | |
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N-(4-Bromobenzil)-2-(5-metoksi-1H-indol-3-il)etanamin | |
Identifikatori | |
ATC kod | none |
PubChem | CID 5124753 |
ChemSpider | 4299315 |
ChEMBL | CHEMBL57427 |
Hemijski podaci | |
Formula | C18H19BrN2O |
Molarna masa | 359,260 g/mol |
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Reference
уреди- ^ Niels Jensen. Tryptamines as Ligands and Modulators of the Serotonin 5-HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens. PhD dissertation, Georg-August-Universität zu Göttingen, 2004.
- ^ Glennon RA, Dukat M, el-Bermawy M, Law H, De los Angeles J, Teitler M, King A, Herrick-Davis K. Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. Journal of Medicinal Chemistry. 1994 Jun 24;37(13):1929-35. PMID 8027974
- ^ Maria Silva PhD. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.
- ^ Silva ME, Heim R, Strasser A, Elz S, Dove S (2011). „Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor”. Journal of Computer-aided Molecular Design. 25 (1): 51—66. PMID 21088982. doi:10.1007/s10822-010-9400-2.