8-OH-DPAT je istraživačka hemikalija iz aminotetralinske hemijske klase koja je razvijena tokom 1980-tih i široko korišćena u ispitivanju funkcije 5-HT1A receptora. On je bio jedan od prvih agonista) 5-HT1A receptora.

8-OH-DPAT
Kekulé, skeletal formula of 8-OH-DPAT
Nazivi
IUPAC naziv
8-Hidroksi-2-(di-n-propilamino)tetralin
Sistemski IUPAC naziv
7-(Dipropilamino)-5,6,7,8-tetrahidronaftalen-1-ol[1]
Identifikacija
3D model (Jmol)
Abrevijacija 8-OH-DPAT
ChemSpider
MeSH 8-Hydroxy-2-(di-N-propylamino)tetralin
  • CCCN(CCC)C1CCc2cccc(O)c2C1
  • CCCN(CCC)C1CCC2=C(C1)C(O)=CC=C2
Svojstva
C16H25NO
Molarna masa 247,38 g·mol−1
log P 3,711
Kiselost (pKa) 10,539
Baznost (pKb) 3,458
Farmakologija
Farmakokinetika:
1,5 sata
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
ДаY verifikuj (šta je ДаYНеН ?)
Reference infokutije

Originalno se verovalo da je selektivan za 5-HT1A receptor. Kasnije je utvrđeno da 8-OH-DPAT takođe deluje kao agonist 5-HT7 receptora i kao inhibitor serotoninskog preuzimanja/agens serotoninskog otpuštanja.[4][5][6][7][8]

Reference

уреди
  1. ^ „8-hydroxy-2-(di-N-propylamino)tetralin - PubChem Public Chemical Database”. The PubChem Project. USA: National Center for Biotechnology Information. 
  2. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди
  3. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  4. ^ Larsson LG, Rényi L, Ross SB, Svensson B, Angeby-Möller K (1990). „Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT”. Neuropharmacology. 29 (2): 85—91. PMID 1691832. doi:10.1016/0028-3908(90)90047-U. 
  5. ^ Sprouse J, Reynolds L, Li X, Braselton J, Schmidt A (2004). „8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production”. Neuropharmacology. 46 (1): 52—62. PMID 14654097. doi:10.1016/j.neuropharm.2003.08.007. 
  6. ^ „IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7. Архивирано из оригинала 03. 03. 2016. г. Приступљено 05. 10. 2012. 
  7. ^ Assié MB, Koek W (1996). „Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats”. British Journal of Pharmacology. 119 (5): 845—50. PMC 1915946 . PMID 8922730. 
  8. ^ Wölfel R, Graefe KH (1992). „Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter”. Naunyn-Schmiedeberg's Archives of Pharmacology. 345 (2): 129—36. PMID 1570019. doi:10.1007/BF00165727. 

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