5-Karboksamidotriptamin

5-Karboksamidotriptamin
IUPAC ime
	3-(2-aminoethyl)-1H-indole-5-carboxamide
Identifikatori
CAS broj	74885-09-9
ATC kod	None
PubChem	CID 1809
IUPHAR/BPS	4
ChemSpider	1743
ChEMBL	CHEMBL18840
Hemijski podaci
Formula	C11H13N3O
Molarna masa	203.240 g/mol
	SMILES C1=CC2=C(C=C1C(=O)N)C(=CN2)CCN; ;
	InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) ; Key:WKZLNEWVIAGNAW-UHFFFAOYSA-N ;

5-Karboksamidotriptamin (5-CT) je triptaminski derivat koji je blisko srodan sa neurotransmiterom serotoninom.

5-CT deluje kao neselektivni pun agonist visokog afiniteta na 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_5A, i 5-HT₇ receptore, kao i na 5-HT₂, 5-HT₃, 5-HT₆ receptore sa nižim afinitetom.^[1]^[2]^[3] On ima neznatan afinitet za 5-HT_1E i 5-HT_1F receptore.^[4] 5-CT se najjače vezuje za 5-HT_1A receptor i nekad se smatralo da je selektivan za njega.^[5]^[6]

Vidi još уреди

Референце уреди

^ Yamada J, Sugimoto Y, Noma T, Yoshikawa T (1998). „Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.”. Eur J Pharmacol. 359 (1): 81—86. PMID 9831297. doi:10.1016/S0014-2999(98)00617-7.
^ Wright, CE; Angus, JA (1989). „5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.”. Journal of cardiovascular pharmacology. 13 (4): 557—64. PMID 2470992.
^ Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 04. 2008.
^ Stanton JA, Middlemiss DN, Beer MS (1996). „Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.”. Neuropharmacology. 35 (2): 223—229. PMID 8734492. doi:10.1016/0028-3908(95)00178-6.
^ Thomas, DR; Middlemiss, DN; Taylor, SG; Nelson, P; Brown, AM (1999). „5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors.”. British journal of pharmacology. 128 (1): 158—64. PMC 1571602  . PMID 10498847. doi:10.1038/sj.bjp.0702759.
^ Saxena, PR; Lawang, A (1985). „A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors.”. Archives internationales de pharmacodynamie et de therapie. 277 (2): 235—52. PMID 2933009.

[pmid9831297-1] Yamada J, Sugimoto Y, Noma T, Yoshikawa T (1998). „Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.”. Eur J Pharmacol. 359 (1): 81—86. PMID 9831297. doi:10.1016/S0014-2999(98)00617-7.

[2] Wright, CE; Angus, JA (1989). „5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.”. Journal of cardiovascular pharmacology. 13 (4): 557—64. PMID 2470992.

[urlSerotonin_Receptor_Subtypes_and_Ligands-3] Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 04. 2008.

[pmid8734492-4] Stanton JA, Middlemiss DN, Beer MS (1996). „Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.”. Neuropharmacology. 35 (2): 223—229. PMID 8734492. doi:10.1016/0028-3908(95)00178-6.

[5] Thomas, DR; Middlemiss, DN; Taylor, SG; Nelson, P; Brown, AM (1999). „5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors.”. British journal of pharmacology. 128 (1): 158—64. PMC 1571602  . PMID 10498847. doi:10.1038/sj.bjp.0702759.

[6] Saxena, PR; Lawang, A (1985). „A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors.”. Archives internationales de pharmacodynamie et de therapie. 277 (2): 235—52. PMID 2933009.

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