2-Metil-5-hidroksitriptamin (2-Metilserotonin, 2-Metil-5-HT) je triptaminski derivat koji je blisko srodan neurotransmiteru serotonin. On deluje kao umereno selektivan agonist 5-HT3 receptora.[1][2][3]

2-Metil-5-hidroksitriptamin
IUPAC ime
3-(2-aminoethyl)-2-methyl-1H-indol-5-ol
Identifikatori
CAS broj78263-90-8
PubChemCID 1574
IUPHAR/BPS218
ChemSpider1518 ДаY
KEGGC13665 ДаY
ChEMBLCHEMBL266591 ДаY
Hemijski podaci
FormulaC11H14N2O
Molarna masa190.242 g/mol
  • Oc1cc2c(cc1)nc(c2CCN)C
  • InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3 ДаY
  • Key:WYWNEDARFVJQSG-UHFFFAOYSA-N ДаY

Vidi još

уреди

Literatura

уреди
  1. ^ Elz S, Zimmermann H, Rehse K (1993). „Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines.”. Arch Pharm (Weinheim). 326 (11): 893—899. PMID 8274071. doi:10.1002/ardp.19933261110. 
  2. ^ Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE (1990). „5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.”. Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9—16. PMID 2402303. 
  3. ^ Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 04. 2008. 


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