1,2-Naftohinon
1,2-Naftohinon (orto-naftohinon) je policiklično aromatično organsko jedinjenje.
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| Nazivi | |
|---|---|
| Drugi nazivi
o-Naftohinon,
β-naftohinon | |
| Identifikacija | |
3D model (Jmol)
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| ChemSpider | |
| ECHA InfoCard | 100.007.602 |
| KEGG[1] | |
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| Svojstva | |
| C10H6O2 | |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je   ?)
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| Reference infokutije | |
Ovaj dvostruki keton (hinon) je reaktivni metabolit naftalina, koji je prisutan je u česticama dizelnih izduvnih gasova. Akumulacija ovog toksičnog metabolita izaziva oštećenje očiju kod pacova, uključujući formiranje katarakti.[4]
Reference
уреди- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Qian, W.; Shichi, H. (2001). „Naphthoquinone-Induced Cataract in Mice: Possible Involvement of Ca2+ Release and Calpain Activation”. Journal of Ocular Pharmacology and Therapeutics. 17 (4): 383—392. PMID 11572469. doi:10.1089/108076801753162799.
Literatura
уреди- Troester, M. A.; Lindstrom, A. B.; Waidyanatha, S.; Kupper, L. L.; Rappaport, S. M. (2002). „Stability of Hemoglobin and Albumin Adducts of Naphthalene Oxide, 1,2-Naphthoquinone, and 1,4-Naphthoquinone” (pdf). Toxicological Sciences. 68 (2): 314—321. PMID 12151627. doi:10.1093/toxsci/68.2.314.
- Kikuno, S.; Taguchi, K.; Iwamoto, N.; et al. (2006). „1,2-Naphthoquinone Activates Vanilloid Receptor 1 through Increased Protein Tyrosine Phosphorylation, Leading to Contraction of Guinea Pig Trachea”. Toxicology and Applied Pharmacology. 210 (1–2): 47—54. PMID 16039679. doi:10.1016/j.taap.2005.06.015.
Vidi još
уреди- 1,4-Naftohinon, izomer 1,2-naftohinona