11-nor-9-karboksi-THC

11-nor-9-karboksi-THC
IUPAC ime
	1-hidroksi-6,6-dimetil-3-pentil-6a,7,8,10a-tetrahidrobenzo[c]hromen-9-karboksilna kiselina
Klinički podaci
Način primene	varijabilne
Pravni status
Pravni status	varijabilan;
Farmakokinetički podaci
Bioraspoloživost	varijabilna
Metabolizam	varijabilan
Poluvreme eliminacije	5,2 do 6,2 dana
Izlučivanje	Variabilna
Identifikatori
CAS broj	64280-14-4
ATC kod	None
PubChem	CID 107885
ChemSpider	97019
Hemijski podaci
Formula	C21H28O4
Molarna masa	344,445 g/mol
	SMILES CCCCCc1cc(c2c(c1)OC(C3C2C=C(CC3)C(=O)O)(C)C)O; ;
	InChI InChI=1S/C21H28O4/c1-4-5-6-7-13-10-17(22)19-15-12-14(20(23)24)8-9-16(15)21(2,3)25-18(19)11-13/h10-12,15-16,22H,4-9H2,1-3H3,(H,23,24) ; Key:YOVRGSHRZRJTLZ-UHFFFAOYSA-N ;

11-nor-9-karboksi-THC (11-nor-9-karboksi-delta-9-tetrahidrokanabinol, 11-COOH-THC, THC-COOH, THC-11-oic kiselina) je glavni sekundarni metabolit THC koji se formira u telu nakon konzumacije kanabisa.

11-COOH-THC se forma u telu oksidacijom aktivnog metabolita 11-hidroksi-THC posredstvom enzima jetre. On se zatim dalje metabolizuje putem konjugacije sa glukuronidom,^[2] čimes se formira u vodi rastvorno jedinjenje, koje se lakše izlučuje iz tela.^[3]

Reference уреди

^ „Δ9-Tetrahydrocannabinol (THC), 11-Hydroxy-THC, and 11-Nor-9-carboxy-THC Plasma Pharmacokinetics during and after Continuous High-Dose Oral THC ”. Архивирано из оригинала 31. 08. 2011. г. Приступљено 10. 06. 2013.
^ Skopp, G; Pötsch, L (2002). „Stability of 11-nor-delta(9)-carboxy-tetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography-tandem mass spectrometry”. Clinical chemistry. 48 (2): 301—6. PMID 11805011.
^ Law, B; Mason, PA; Moffat, AC; King, LJ (1984). „Confirmation of cannabis use by the analysis of delta 9-tetrahydrocannabinol metabolites in blood and urine by combined HPLC and RIA”. Journal of analytical toxicology. 8 (1): 19—22. PMID 6323852.

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[1] „Δ9-Tetrahydrocannabinol (THC), 11-Hydroxy-THC, and 11-Nor-9-carboxy-THC Plasma Pharmacokinetics during and after Continuous High-Dose Oral THC ”. Архивирано из оригинала 31. 08. 2011. г. Приступљено 10. 06. 2013.

[2] Skopp, G; Pötsch, L (2002). „Stability of 11-nor-delta(9)-carboxy-tetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography-tandem mass spectrometry”. Clinical chemistry. 48 (2): 301—6. PMID 11805011.

[3] Law, B; Mason, PA; Moffat, AC; King, LJ (1984). „Confirmation of cannabis use by the analysis of delta 9-tetrahydrocannabinol metabolites in blood and urine by combined HPLC and RIA”. Journal of analytical toxicology. 8 (1): 19—22. PMID 6323852.

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