Adenilatna ciklaza
(преусмерено са Adenilat ciklaza)
Adenilat ciklaza (EC 4.6.1.1, adenilil ciklaza, adenil ciklaza, AC) je liazni enzim. On je deo cAMP-zavisnog puta.[1]
| Adenilatna ciklaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.6.1.1 | ||||||||
| CAS broj | 9012-42-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| Ontologija gena | AmiGO / EGO | ||||||||
| |||||||||
TipoviУреди
Poznato je deset tipova adenilat ciklaze kod sisara:
- ADCY1
- ADCY2
- ADCY3
- ADCY4
- ADCY5
- ADCY6
- ADCY7
- ADCY8
- ADCY9
- ADCY10
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
ReakcijaУреди
Adenilat ciklaza katalizuje ATP konverziju u 3',5'-ciklični AMP (cAMP) i pirofosfat.
cAMP (ciklični adenozin monofosfat) je važan molekul u eukariotskoj transdukcija signala. On je takozvani sekundarni glasnik. Adenilat ciklaza može biti aktivirana ili inhibirana G proteinima, koji su spregnuti sa membranom receptora i tako može da proizvodi respons na hormonske i druge stimuluse. Nakon aktivacije adenilat ciklaze, rezultujući cAMP dejstvuje kao sekundarni glasnik interagujući sa i regulišući druge proteine, poput protein kinaze A i ciklični nukleotid kontrolisanih jonskih kanala.
ReferenceУреди
- ^ Bruce Alberts; Alexander Johnson; Julian Lewis; Martin Raff; Keith Roberts; Peter Walter (2002). Molecular Biology of the Cell. New York: Garlard Science. ISBN 0815332181.
LiteraturaУреди
РеференцеУреди
LiteraturaУреди
- Sodeman, Thomas M.; Sodeman, William A. (1985). „Physiologic- and Adenylate Cyclase-Coupled Beta-Adrenergic Receptors”. Sodeman's Pathologic physiology: mechanisms of disease. Philadelphia: Saunders. стр. 143—145.
- Benovic JL, Bouvier M, Caron MG, Lefkowitz RJ (1988). „Regulation of adenylyl cyclase-coupled beta-adrenergic receptors”. Annu. Rev. Cell Biol. 4: 405—28. PMID 2848553. doi:10.1146/annurev.cb.04.110188.002201.
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje vezeУреди
- Adenylate+cyclase на US National Library of Medicine Medical Subject Headings (MeSH)
- Interaktivni 3D prikaz adenilat ciklaze - Proteopedia Adenylyl_cyclase