CP-226,269

CP-226,269
IUPAC ime
	5-fluoro-2-[(4-piridin-2-ilpiperazin-1-il)metil]-1H-indol
Identifikatori
CAS broj	220941-93-5
ATC kod	none
PubChem	CID 9796720
ChemSpider	7972486
ChEMBL	CHEMBL77395
Hemijski podaci
Formula	C18H19FN4
Molarna masa	310,368 g/mol
	SMILES n4ccccc4N3CCN(CC3)Cc2cc1cc(F)ccc1n2; ;
	InChI InChI=1S/C18H19FN4/c19-15-4-5-17-14(11-15)12-16(21-17)13-22-7-9-23(10-8-22)18-3-1-2-6-20-18/h1-6,11-12,21H,7-10,13H2 ; Key:PQOIDBZLMJMYCD-UHFFFAOYSA-N ;

CP-226,269 je lek koji deluje kao dopaminski agonist. On je selektivan za D₄ podtip. CP-226,269 se koristi za istraživanje uloge D4 receptora u mozgu.^[1]^[2]

Reference

^ Sharma A, Kramer ML, Wick PF, Liu D, Chari S, Shim S, Tan W, Ouellette D, Nagata M, DuRand CJ, Kotb M, Deth RC (1999). „D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia”. Molecular Psychiatry. 4 (3): 235—46. PMID 10395213. doi:10.1038/sj.mp.4000522.
^ Basso AM, Gallagher KB, Bratcher NA, Brioni JD, Moreland RB, Hsieh GC, Drescher K, Fox GB, Decker MW, Rueter LE (2005). „Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test”. Neuropsychopharmacology. 30 (7): 1257—68. PMID 15688083. doi:10.1038/sj.npp.1300677.

Spoljašnje veze

[pmid10395213-1] Sharma A, Kramer ML, Wick PF, Liu D, Chari S, Shim S, Tan W, Ouellette D, Nagata M, DuRand CJ, Kotb M, Deth RC (1999). „D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia”. Molecular Psychiatry. 4 (3): 235—46. PMID 10395213. doi:10.1038/sj.mp.4000522.

[pmid15688083-2] Basso AM, Gallagher KB, Bratcher NA, Brioni JD, Moreland RB, Hsieh GC, Drescher K, Fox GB, Decker MW, Rueter LE (2005). „Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test”. Neuropsychopharmacology. 30 (7): 1257—68. PMID 15688083. doi:10.1038/sj.npp.1300677.

[1]

[2]