CY-208,243 je lek koji deluje kao selektivni dopaminski agonist za D1 podtipe. Za razliku od većene D1-selektivnih agonista, on je pokazao efikasnot u životinjskim modelima za Parkinsonovu bolest.[1][2][3][4][5]

CY-208243
IUPAC ime
4,6,6a,7,8,12b-heksahidro-7-metilindolo(4,3-ab)-fenantridin
Identifikatori
CAS broj100999-26-6 ДаY
ATC kodnone
PubChemCID 58144
Hemijski podaci
FormulaC19H18N2
Molarna masa274,359 g/mol
  • c15c4ncc5CC2C(c1ccc4)c3ccccc3CN2C

Reference

уреди
  1. ^ Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (1995). „Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors”. Progress in Neuro-psychopharmacology & Biological Psychiatry. 19 (4): 667—76. PMID 8588064. 
  2. ^ Beninger RJ, Rolfe NG (1995). „Dopamine D1-like receptor agonists impair responding for conditioned reward in rats”. Behavioural Pharmacology. 6 (8): 785—793. PMID 11224381. 
  3. ^ Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). „Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys”. Advances in Neurology. 69: 239—44. PMID 8615134. 
  4. ^ D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (2003). „Dopamine D1 receptor agonists induce penile erections in rats”. European Journal of Pharmacology. 460 (1): 71—4. PMID 12535862. doi:10.1016/S0014-2999(02)02881-9. 
  5. ^ Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (2005). „Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243”. Behavioural Brain Research. 156 (2): 173—9. PMID 15582103. doi:10.1016/j.bbr.2004.05.019. 

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уреди


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