DPI-3290

DPI-3290
IUPAC ime
	(+)-3-((αR)-α-((2S,5R)-4-Alil-2,5-dimetil-1-piperazinil)-3-hidroksibenzil)-N-(3-fluorofenil)-N-metilbenzamid
Identifikatori
ATC kod	none
PubChem	CID 5242141
Hemijski podaci
Formula	C30H34FN3O2
Molarna masa	487.607 g/mol
	SMILES c2c(O)cccc2C(N(CC1C)C(C)CN1CC=C)c(ccc3)cc3C(=O)N(C)c4cc(F)ccc4; ;

DPI-3290 je lek koji se koristi u naučnim istraživanjima. On je potentan analgetik,^[1] koji zaziva neznatnu respiratornu depresiju.^[2]

DPI-3290 deluje kao agonist μ- i δ-opioidnog receptora, sa IC50 vrednošću od 6.2 nM na μ i 1.0 nM na δ.^[3]

Reference

^ Gengo, PJ; Pettit, HO; O'Neill, SJ; Wei, K; McNutt, R; Bishop, MJ; Chang, KJ (2003). „DPI-3290 (+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide. I. A mixed opioid agonist with potent antinociceptive activity”. The Journal of Pharmacology and Experimental Therapeutics. 307 (3): 1221—6. PMID 14534368. S2CID 93569860. doi:10.1124/jpet.103.054361.
^ Gengo, PJ; Pettit, HO; O'Neill, SJ; Su, YF; McNutt, R; Chang, KJ (2003). „DPI-3290 (+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function”. The Journal of Pharmacology and Experimental Therapeutics. 307 (3): 1227—33. PMID 14534367. S2CID 45159720. doi:10.1124/jpet.103.054429.
^ Ananthan, S. (2006). „Opioid ligands with mixed mu/Delta opioid receptor interactions: An emerging approach to novel analgesics”. The AAPS Journal. 16584118 (1): E118—25. PMC 2751430  . PMID 16584118. doi:10.1208/aapsj080114.

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