Deramciklan
Deramciklan (EGIS-3886) je lek koji deluje kao antagonist na 5-HT2A receptoru,[1] kao inverzni agonist na 5-HT2C receptoru,[2] i kao inhibitor GABA preuzimanja.[3]
 | |
| IUPAC ime | |
|---|---|
N,N-dimetil-2-([(1R,4R,6S)-1,7,7-trimetil-6-fenil-6-biciklo[2.2.1]heptanil]oksi)etanamin | |
| Identifikatori | |
| CAS broj | 120444-72-6  |
| ATC kod | none |
| PubChem | CID 119590 |
| UNII | O5KFK61E74 |
| Hemijski podaci | |
| Formula | C20H31NO |
| Molarna masa | 301,466 g/mol |
| |
Reference уреди
- ^ Kanerva, H.; Vilkman, H.; Någren, K.; Kilkku, O.; Kuoppamäki, M.; Syvälahti, E.; Hietala, J. (1999). „Brain 5-HT2A receptor occupancy of deramciclane in humans after a single oral administration--a positron emission tomography study”. Psychopharmacology. 145 (1): 76—81. PMID 10445375. doi:10.1007/s002130051034.
- ^ Pälvimäki, E. P.; Majasuo, H.; Kuoppamäki, M.; Männistö, P. T.; Syvälahti, E.; Hietala, J. (1998). „Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation”. Psychopharmacology. 136 (2): 99—104. PMID 9551765. doi:10.1007/s002130050544.
- ^ Kovács, I.; Maksay, G.; Simonyi, M. (1989). „Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative”. Arzneimittel-Forschung. 39 (3): 295—297. PMID 2502985.
