JNJ 7777120
JNJ-7777120 je lek koji je razvila kompanija Džonson & Džonson. On deluje kao potentan i selektivan antagonist histaminskog H4 receptora.[1] On ima antiinflamatorno dejstvo.[2] Pokazano je da je superioran u odnosu na traditionalne antihistamine u treatmanu pruritusa (svraba).[3]
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| IUPAC ime | |
|---|---|
5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-indol | |
| Identifikatori | |
| CAS broj | 459168-41-3  |
| ATC kod | none |
| PubChem | CID 4908365 |
| IUPHAR/BPS | 1278 |
| ChEMBL | CHEMBL129198 |
| Sinonimi | 1-[(5-hloro-1H-indol-2-il)karbonil]-4-metilpiperazin |
| Hemijski podaci | |
| Formula | C14H16ClN3O |
| Molarna masa | 277,749 g/mol |
| |
Reference
уреди- ^ Jiang W; Lim, HD; Zhang M; et al. (2008). „Cloning and pharmacological characterization of the dog histamine H(4) receptor”. Eur. J. Pharmacol. 592 (1–3): 26—32. PMID 18639542. doi:10.1016/j.ejphar.2008.06.095.
- ^ Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. Thurmond, R. L.; Desai, P. J.; Dunford, P. J.; Fung-Leung, W. P.; Hofstra, C. L.; Jiang, W.; Nguyen, S.; Riley, J. P.; Sun, S.; Williams, K. N.; Edwards, J. P.; Karlsson, L. (април 2004). „A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties”. Journal of Pharmacology and Experimental Therapeutics. 309 (1): 404—13. PMID 14722321. doi:10.1124/jpet.103.061754.
- ^ Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Dunford, P. J.; Williams, K. N.; Desai, P. J.; Karlsson, L.; McQueen, D.; Thurmond, R. L. (јануар 2007). „Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus”. Journal of Allergy and Clinical Immunology. 119 (1): 176—83. PMID 17208599. doi:10.1016/j.jaci.2006.08.034.
