LY-293,284

LY-293,284
IUPAC ime
	(4R)-6-acetil-4-(di-n-propilamino)-1,3,4,5-tetrahidrobenz[c,d]indol
Identifikatori
CAS broj	141318-62-9
ATC kod	None
PubChem	CID 132345
Hemijski podaci
Formula	C19H26N2O
Molarna masa	298,423 g/mol
	SMILES CCCN(CCC)[C@H]1CC2=CNC3=C2C(=C(C=C3)C(=O)C)C1; ;

LY-293,284 je istraživačka hemikalija. On deluje kao potentan i selektivan pun agonist 5-HT_1A receptora. On je izveden putem nekoliko strukturnih simplifikacija na ergolinu baziranih halucinogena, LSD^[1] On je selektivan za 5-HT_1A sa preko 1000x selektivnošću u odnosu na druge tipove serotoninskog receptora i druge ciljeve.^[2] On pokazuje anksiogene efekte u životinjskim studijama.^[3]

Reference уреди

^ Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE (1998). „Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity”. Journal of Medicinal Chemistry. 41 (12): 2134—45. PMID 9622555. doi:10.1021/jm980076u.
^ Foreman MM, Fuller RW, Rasmussen K, Nelson DL, Calligaro DO, Zhang L, Barrett JE, Booher RN, Paget CJ, Flaugh ME (1994). „Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity”. The Journal of Pharmacology and Experimental Therapeutics. 270 (3): 1270—81. PMID 7523657.
^ Cao BJ, Rodgers RJ (1998). „Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice”. Psychopharmacology. 139 (3): 185—94. PMID 9784072. doi:10.1007/s002130050703.

Spoljašnje veze уреди

[pmid9622555-1] Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE (1998). „Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity”. Journal of Medicinal Chemistry. 41 (12): 2134—45. PMID 9622555. doi:10.1021/jm980076u.

[pmid7523657-2] Foreman MM, Fuller RW, Rasmussen K, Nelson DL, Calligaro DO, Zhang L, Barrett JE, Booher RN, Paget CJ, Flaugh ME (1994). „Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity”. The Journal of Pharmacology and Experimental Therapeutics. 270 (3): 1270—81. PMID 7523657.

[pmid9784072-3] Cao BJ, Rodgers RJ (1998). „Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice”. Psychopharmacology. 139 (3): 185—94. PMID 9784072. doi:10.1007/s002130050703.

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