LY-307,452
LY-307,452 je lek koji se koristi u naučnim istraživanjima. On je bio među prvim jedinjenjima koja su delovala kao selektivni antagonisti za grupu II metabotropnih glutamatnih receptora (mGluR2/3),[1] i bio je koristan u ranim ispitivanjima te receptorske familije,[2][3] mada je u međuvremenu uglavnom zamenjen novijim lekovima poput LY-341,495.
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| IUPAC ime | |
|---|---|
(2S,4S)-2-amino-4-(4,4-difenilbut-1-il)pentan-1,5-dioiska kiselina | |
| Identifikatori | |
| ATC kod | none |
| PubChem | CID 6324634 |
| Hemijski podaci | |
| Formula | C21H25NO4 |
| Molarna masa | 355,428 g/mol |
| |
Reference уреди
- ^ Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD (1996). „(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase”. Journal of Medicinal Chemistry. 39 (4): 814—6. PMID 8632404. doi:10.1021/jm9508144.
- ^ Li XC, Beart PM, Monn JA, Jones NM, Widdop RE (1999). „Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats”. British Journal of Pharmacology. 128 (3): 823—9. PMC 1571690
. PMID 10516668. doi:10.1038/sj.bjp.0702850.
- ^ Sung KW, Choi S, Lovinger DM (2001). „Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses”. Journal of Neurophysiology. 86 (5): 2405—12. PMID 11698530.
