N6-Metiladenozin
N6-Metiladenozin (m6A ) je često prisutan u iRNK i prisutan je u nekim virusima,[3][4] i većini eukariota uključujući sisare,[5][6][7][8] insekte,[9] biljke[10][11][12] i kvasce.[13][14] On je takoše nađen u tRNK, rRNK, i snRNK kao i u nekoliko dugo kodirajućih RNK, poput Xist.[15][16]
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| Nazivi | |
|---|---|
| IUPAC naziv
N-Metiladenozin
| |
| Drugi nazivi
m6A
| |
| Identifikacija | |
3D model (Jmol)
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| ChemSpider | |
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| Svojstva | |
| C11H15N5O4 | |
| Molarna masa | 281,27 g·mol−1 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
| Reference infokutije | |
Reference уреди
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Beemon K, Keith J (1977). „Localization of N6-methyladenosine in the Rous sarcoma virus genome”. J. Mol. Biol. 113 (1): 165—79. PMID 196091. doi:10.1016/0022-2836(77)90047-X.
- ^ Aloni Y, Dhar R, Khoury G (1979). „Methylation of nuclear simian virus 40 RNAs”. J. Virol. 32 (1): 52—60. PMC 353526
. PMID 232187.
- ^ Desrosiers R, Friderici K, Rottman F (1974). „Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells”. Proc. Natl. Acad. Sci. U.S.A. 71 (10): 3971—5. PMC 434308 . PMID 4372599. doi:10.1073/pnas.71.10.3971.
- ^ Adams JM, Cory S (1975). „Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA”. Nature. 255 (5503): 28—33. PMID 1128665. doi:10.1038/255028a0.
- ^ Wei CM, Gershowitz A, Moss B (1976). „5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA”. Biochemistry. 15 (2): 397—401. PMID 174715. doi:10.1021/bi00647a024.
- ^ Perry RP, Kelley DE, Friderici K, Rottman F (1975). „The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus”. Cell. 4 (4): 387—94. PMID 1168101. doi:10.1016/0092-8674(75)90159-2.
- ^ Levis R, Penman S (1978). „5'-terminal structures of poly(A)+ cytoplasmic messenger RNA and of poly(A)+ and poly(A)- heterogeneous nuclear RNA of cells of the dipteran Drosophila melanogaster”. J. Mol. Biol. 120 (4): 487—515. PMID 418182. doi:10.1016/0022-2836(78)90350-9.
- ^ Nichols JL (1979). „In maize poly(A)-containing RNA”. Plant Science Letters. 15 (4): 357. doi:10.1016/0304-4211(79)90141-X.
- ^ Kennedy TD, Lane BG (1979). „Wheat embryo ribonucleates. XIII. Methyl-substituted nucleoside constituents and 5'-terminal dinucleotide sequences in bulk poly(AR)-rich RNA from imbibing wheat embryos”. Can. J. Biochem. 57 (6): 927—31. PMID 476526. doi:10.1139/o79-112.
- ^ Zhong S, Li H, Bodi Z, Button J, Vespa L, Herzog M, Fray RG (2008). „MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor”. Plant Cell. 20 (5): 1278—88. PMC 2438467 . PMID 18505803. doi:10.1105/tpc.108.058883.
- ^ Clancy MJ, Shambaugh ME, Timpte CS, Bokar JA (2002). „Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene”. Nucleic Acids Res. 30 (20): 4509—18. PMC 137137 . PMID 12384598. doi:10.1093/nar/gkf573.
- ^ Bodi Z, Button JD, Grierson D, Fray RG (2010). „Yeast targets for mRNA methylation”. Nucleic Acids Res. 38 (16): 5327—35. PMC 2938207 . PMID 20421205. doi:10.1093/nar/gkq266.
- ^ Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR (2012). „Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3' UTRs and near Stop Codons”. Cell. 149 (7): 1635—46. PMID 22608085. doi:10.1016/j.cell.2012.05.003.
- ^ Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G (2012). „Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq”. Nature. 485 (7397): 201—6. PMID 22575960. doi:10.1038/nature11112.
