Nesiritid
Nesiritid (Natrecor) je rekombinantna forma 32 aminokiseline dugog ljudskog B-tipa natriuretskog peptida, koji se prirodno formira u ventrikularnom miokardijumu. Nesiritid deluje tako što posreduje homeostazu kardiovaskularnog fluida putem regulacije renin-angiotenzin-aldoesteronskog sistema, stimulacije cikličnog guanozin monofosfata, što dovodi do relaksacije glatkih mišića.[1][2][3][4][5][6][7]
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Način primene | Intravenozno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 18 minuta |
| Identifikatori | |
| CAS broj | 124584-08-3  |
| ATC kod | C01DX19 (WHO) |
| PubChem | CID 16134381 |
| DrugBank | DB04899 |
| ChEMBL | CHEMBL1201668 |
| Hemijski podaci | |
| Formula | C143H244N50O42S4 |
| Molarna masa | 3464 |
Reference
уреди- ^ Jefferies JL, Price JF, Denfield SW, Chang AC, Dreyer WJ, McMahon CJ, Grenier MA, Clunie SK, Thomas A, Moffett BS, Wann TS, Smith EO, Towbin JA: Safety and efficacy of nesiritide in pediatric heart failure. J Card Fail. 2007 Sep;13(7):541-8. PMID 17826644
- ^ Maisel AS: Nesiritide: a new therapy for the treatment of heart failure. Cardiovasc Toxicol. 2003;3(1):37-42. PMID 12668889
- ^ Vichiendilokkul A, Tran A, Racine E: Nesiritide: a novel approach for acute heart failure. Ann Pharmacother. 2003 Feb;37(2):247-58. PMID 12549957
- ^ Cheng JW: Nesiritide: review of clinical pharmacology and role in heart failure management. Heart Dis. 2002 May-Jun;4(3):199-203. PMID 12028606
- ^ Bettencourt P: Brain natriuretic peptide (nesiritide) in the treatment of heart failure. Cardiovasc Drug Rev. 2002 Winter;20(1):27-36. PMID 12070532
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
Literatura
уреди- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
уреди
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