PD-0298029
PD-0298029 je lek koji deluje kao selektivni antagonist za muskarinski acetilholinski receptor M4. On je razvijen za lečenje Parkinsonove bolesti, ali je zbog slabe biodostupnosti i brzog metabolizma njegova primena u životinjskim studijama ograničena. On se prvenstveno koristi u in vitro istraživanjima M4 i drugih muskarinskih receptora.[1][2][3]
IUPAC ime | |
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etil 3,6a,11,14-tetrahidro-9-metoksi-2-propil-3,5-dimetil-(12H)-izohino[1,2-b]pirolo[3,2-f][1,3]benzoksazin-1-karboksilat | |
Identifikatori | |
ATC kod | none |
ChemSpider | 26233369 |
Hemijski podaci | |
Formula | C27H32N2O4 |
Molarna masa | 448,56 g·mol−1 |
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Reference
уреди- ^ Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD (2002). „Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors”. Journal of Medicinal Chemistry. 45 (14): 3094—102. PMID 12086495. doi:10.1021/jm011116o.
- ^ Boehme TM, Angelli-Szafran CE, Corinne E, Hallak H and Schwarz RD. Analogs of M4 selective synthetic muscarinic receptor antagonists: Synthesis, binding and pharmacokinetic properties. Medicinal Chemistry Research. 2002; 11(8):423–433.
- ^ Progress in Medicinal Chemistry 43. (2005). Chapter 4, Muscarinic Receptor Subtype Pharmacology and Physiology, by Richard M Eglen. pp 128-129. ISBN 0-444-51572-0