PNU-22394

PNU-22394
IUPAC ime
	6-Metil-1,2,3,4,5,6-heksahidro-azepino[4,5-b]indol
Identifikatori
CAS broj	15923-78-1
ATC kod	none
PubChem	CID 27559
ChEMBL	CHEMBL6557
Hemijski podaci
Formula	C13H16N2
Molarna masa	200,279 g/mol
	SMILES C3CNCCc2c3c1ccccc1n2C; ;

PNU-22394 je lek koji deluje kao agonist na serotoninskim 5-HT₂ receptorima, sa većim afinitetom vezivanja za 5-HT_2A i 5-HT_2C i nešto manjim za 5-HT_2B, mada je on pun agonist 5-HT_2C, a parcijalni agonist za 5-HT_2A i 5-HT_2B. On proizvodi anoreksične efekte kod životinja i ljudi. Ovaj lek nije razvijen meri neophodnoj za medicinsku upotrebu.^[1]^[2]

Reference уреди

^ McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW. PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans. Soc Neurosci Abstr. 2001;27,309.302.
^ Garfield AS; Heisler LK (2009). „Pharmacological targeting of the serotonergic system for the treatment of obesity”. The Journal of Physiology. 587 (Pt 1): 49—60. PMC 2670022  . PMID 19029184. doi:10.1113/jphysiol.2008.164152.

Vidi još уреди

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Spoljašnje veze уреди

[1] McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW. PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans. Soc Neurosci Abstr. 2001;27,309.302.

[pmid19029184-2] Garfield AS; Heisler LK (2009). „Pharmacological targeting of the serotonergic system for the treatment of obesity”. The Journal of Physiology. 587 (Pt 1): 49—60. PMC 2670022  . PMID 19029184. doi:10.1113/jphysiol.2008.164152.

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