RS-67333
RS-67,333 je psihoaktivni lek i istraživačka hemikalija koja se ispituje kao potencijalni brzo delujući antidepresiv,[1] nootropik,[2] i tretman za Alchajmerovu bolest.[3] On ima parcijalni agonist visokog afiniteta za 5-HT4 receptor, kao i ligand za sigma receptor sa preferencijom za σ1 tip.[4]
 | |
| IUPAC ime | |
|---|---|
1-(4-amino-5-hloro-2-metoksifenil)-3-(1-butil-4-piperidinil)-1-propanon | |
| Identifikatori | |
| CAS broj | 160845-95-4  |
| ATC kod | none |
| Hemijski podaci | |
| Formula | C19H29N2O2 |
| Molarna masa | 352,9 g/mol |
| |
Reference
уреди- ^ Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G (2007). „Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action.”. Neuron. 55 (5): 712–25. PMID 17785179. doi:10.1016/j.neuron.2007.07.041.
- ^ Lamirault L, Simon H (2001). „Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors.”. Neuropharmacology. 41 (7): 844–53. PMID 11684148. doi:10.1016/S0028-3908(01)00123-X.
- ^ Cho S, Hu Y (2007). „Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.”. Experimental Neurology. 203 (1): 274–8. PMID 16978609. doi:10.1016/j.expneurol.2006.07.021.
- ^ Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD (1995). „Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo”. Br. J. Pharmacol. 115 (8): 1387—92. PMC 1908873
. PMID 8564196.
