VER-3323
VER-3323 je lek koji deluje kao selektivni agonist 5-HT2B i 5-HT2C serotoninskih receptora, sa umerenom selektivnošću za 5-HT2C, i relativno niskim afinitetom za 5-HT2A. U životinjskim studijama je utvrđeno da je on potentan anoreksik .[1][2][3][4]
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| IUPAC ime | |
|---|---|
(2S)-1-(6-bromo-2,3-dihidroindol-1-il)propan-2-amin | |
| Identifikatori | |
| PubChem | CID 6604042 |
| Hemijski podaci | |
| Formula | C11H15BrN2 |
| Molarna masa | 255,154 g/mol |
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Vidi još уреди
Literatura уреди
- ^ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (2004). „Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors”. Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114—23. PMID 15322733. doi:10.1007/s00210-004-0951-4.
- ^ Halford JC, Harrold JA, Lawton CL, Blundell JE (2005). „Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity”. Current Drug Targets. 6 (2): 201—13. PMID 15777190.
- ^ Schuhler S, Clark A, Joseph W, Patel A, Lehnen K, Stratford E, Horan TL, Fone KC, Ebling FJ (2005). „Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters”. Journal of Neuroendocrinology. 17 (5): 276—85. PMID 15869562. doi:10.1111/j.1365-2826.2005.01303.x.
- ^ Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A (2005). „Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes”. Assay and Drug Development Technologies. 3 (6): 649—59. PMID 16438660. doi:10.1089/adt.2005.3.649.
Spoljašnje veze уреди
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
