VUF-6002 (JNJ 10191584) je lek koji deluje kao potentan i selektivan antagonist histaminskog H4 receptora.[1] On pokazuje antiinflamatorne i analgetske efekte u ispitivanjima akutne inflamacije na životinjama.[2]

VUF-6002
IUPAC ime
5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-benzimidazol
Identifikatori
CAS broj869497-75-6 ДаY
ATC kodnone
PubChemCID 10446295
IUPHAR/BPS1277
Hemijski podaci
FormulaC13H15ClN4O
Molarna masa278,737 g/mol
  • n2c1ccc(Cl)cc1nc2C(=O)N3CCN(C)CC3

Reference

уреди
  1. ^ Zhang, M; Thurmond, RL; Dunford, PJ (2007). „The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders”. Pharmacology & therapeutics. 113 (3): 594—606. PMID 17275092. doi:10.1016/j.pharmthera.2006.11.008. 
  2. ^ Coruzzi, G; Adami, M; Guaita, E; De Esch, IJ; Leurs, R (2007). „Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation”. European Journal of Pharmacology. 563 (1–3): 240—4. PMID 17382315. doi:10.1016/j.ejphar.2007.02.026. 

Spoljašnje veze

уреди