VUF-6002
VUF-6002 (JNJ 10191584) je lek koji deluje kao potentan i selektivan antagonist histaminskog H4 receptora.[1] On pokazuje antiinflamatorne i analgetske efekte u ispitivanjima akutne inflamacije na životinjama.[2]
 | |
| IUPAC ime | |
|---|---|
5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-benzimidazol | |
| Identifikatori | |
| CAS broj | 869497-75-6  |
| ATC kod | none |
| PubChem | CID 10446295 |
| IUPHAR/BPS | 1277 |
| Hemijski podaci | |
| Formula | C13H15ClN4O |
| Molarna masa | 278,737 g/mol |
| |
Reference
уреди- ^ Zhang, M; Thurmond, RL; Dunford, PJ (2007). „The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders”. Pharmacology & therapeutics. 113 (3): 594—606. PMID 17275092. doi:10.1016/j.pharmthera.2006.11.008.
- ^ Coruzzi, G; Adami, M; Guaita, E; De Esch, IJ; Leurs, R (2007). „Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation”. European Journal of Pharmacology. 563 (1–3): 240—4. PMID 17382315. doi:10.1016/j.ejphar.2007.02.026.
