WAY-213,613
WAY-213,613 je lek koji deluje kao inhibitor preuzimanja za podtip glutamatnog transportera EAAT2. On je selektivan u odnosu na druge podtipove glutamatnih transportera, i visoko je selektivan u odnosu na metabotropne i jonotropne glutamatne receptore.[1] It is used in scientific research into the function of the glutamate transporters.[2]
 | |
| IUPAC ime | |
|---|---|
(2S)-2-amino-4-[4-(2-bromo-4,5-difluorofenoksi)anilino]-4-oksobutanoinska kiselina | |
| Identifikatori | |
| CAS broj | 868359-05-1  |
| ATC kod | none |
| PubChem | CID 11531745 |
| Hemijski podaci | |
| Formula | C16H13BrF2N2O4 |
| Molarna masa | 415,186 g/mol |
| |
Reference
уреди- ^ Dunlop, J; McIlvain, HB; Carrick, TA; Jow, B; Lu, Q; Kowal, D; Lin, S; Greenfield, A; et al. (2005). „Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2”. Molecular Pharmacology. 68 (4): 974—82. PMID 16014807. doi:10.1124/mol.105.012005.
- ^ Karatas-Wulf, U; Koepsell, H; Bergert, M; Sönnekes, S; Kugler, P (2009). „Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells”. Neuroscience. 161 (3): 794—805. PMID 19364521. doi:10.1016/j.neuroscience.2009.04.017.
