APICA (lek)

APICA
IUPAC ime
	1-Amino-5-fosfonoindan-1-karboksilna kiselina
Identifikatori
ATC kod	none
ChemSpider	3881975
ChEMBL	CHEMBL277961
Hemijski podaci
Formula	C10H12NO5P
Molarna masa	257,179 g/mol
	SMILES O=P(O)(O)c(c2)ccc1c2CCC1(N)C(O)=O; ;
	InChI InChI=1S/C10H12NO5P/c11-10(9(12)13)4-3-6-5-7(17(14,15)16)1-2-8(6)10/h1-2,5H,3-4,11H2,(H,12,13)(H2,14,15,16) ; Key:ZNQZXIHSJUDIKL-UHFFFAOYSA-N ;

1-Amino-5-fosfonoindan-1-karboksilna kiselina (APICA) je lek koji se koristi u neurološkim istraživanjima. on je selektivni antagonist za grupu II metabotropnih glutamatnih receptora (mGluR_2/3), i bio je koristan u istraživanju te receptorske potfamilije.^[1]^[2]^[3]^[4]^[5]

Reference

^ Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Bioorganic & Medicinal Chemistry Letters. 1997 May 6;7(9):1195-1198. „Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists”. doi:10.1016/S0960-894X(97)00177-7.
^ Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. Journal of Organic Chemistry. 1999 Jan 8;64(1):120-125. PMID 11674092
^ Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Journal of Pharmacology and Experimental Therapeutics. 2002 Jan;300(1):162-71. „Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens”. PMID 11752112. doi:10.1124/jpet.300.1.162.
^ Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. Journal of Neuroscience. 2002 Oct 15;22(20):9134-41. PMID 12388621
^ Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G. Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. Journal of Neuroscience Research. 2006 Aug 1;84(2):268-77. PMID 16752416

Spoljašnje veze

[1] Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Bioorganic & Medicinal Chemistry Letters. 1997 May 6;7(9):1195-1198. „Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists”. doi:10.1016/S0960-894X(97)00177-7.

[2] Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. Journal of Organic Chemistry. 1999 Jan 8;64(1):120-125. PMID 11674092

[3] Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Journal of Pharmacology and Experimental Therapeutics. 2002 Jan;300(1):162-71. „Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens”. PMID 11752112. doi:10.1124/jpet.300.1.162.

[4] Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. Journal of Neuroscience. 2002 Oct 15;22(20):9134-41. PMID 12388621

[5] Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G. Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. Journal of Neuroscience Research. 2006 Aug 1;84(2):268-77. PMID 16752416

[1]

[2]

[3]

[4]

[5]