Geosminska sintaza
Geosminska sintaza (EC 4.1.99.16) je enzim sa sistematskim imenom germakradienol geosmin-lijaza (formira aceton).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Geosminska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.99.16 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (1E,4S,5E,7R)-germakra-1(10),5-dien-11-ol + H2O (-)-geosmin + aceton
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference
uredi- ^ Jiang, J., He, X. and Cane, D.E. (2006). „Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin”. J. Am. Chem. Soc. 128: 8128—8129. PMID 16787064.
- ^ Cane, D.E., He, X., Kobayashi, S., Omura, S. and Ikeda, H. (2006). „Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase”. J. Antibiot. (Tokyo). 59: 471—479. PMID 17080683.
- ^ Jiang, J., He, X. and Cane, D.E. (2007). „Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme”. Nat. Chem. Biol. 3: 711—715. PMID 17873868.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
uredi- Geosmin+synthase na US National Library of Medicine Medical Subject Headings (MeSH)